000			05776nam a22003977a 4500
001			CUHAS/MMED/6000235/T/16
003			CUHAS/MMED/6000235/T/16
005			20240418155841.0
008			210821b |||||||| |||| 00| 0 eng d
028			_bWurzburg Road 35, BMC Premises, Post Code: 33102:
028			_b P. O Box 1464, Mwanza – Tanzania:
028			_bPhone: +255 28 298 3384:
028			_bFax: +255 28 298 3386:
028			_bEmail: vc@bugando.ac.tz :
028			_bwww.bugando.ac.tz
035			_aCUHAS/MMED/6000235/T/16
040			_bEnglish _cddc
041			_aEnglish
100			_a Ernest M Celestine _d[Male] _922762 _eCUHAS/MMED/6000235/T/16
210			_aABBREVIATIONS _bBMC Bugando Medical Centre BPLND Bilateral Pelvic Lymph Node Dissection CCRT Combined Chemo – Radiotherapy CT Computed Tomography CUHAS Catholic University of Health and Allied Sciences DFS ehms# Disease Free Survival Electronic health management system number FIGO International Federation of Obstetrician and Gynecologists MRI Magnetic Resonance Imaging NACT Neo Adjuvant Chemotherapy OBGYN Obstetrics and Gynecology ORCI Ocean Road Cancer Institute OS Overall Survival Rate PET-CT Positron emission tomography- Computed tomography PFS Progression Free Survival RHT Radical Hysterectomy RT Radiation Therapy
222			_aOPERATIONAL DEFINITION _bSurvival outcomes This involves disease free survival, recurrence and death
222			_aOPERATIONAL DEFINITION _bRecurrence Means occurrence of disease symptoms and clinical signs after being declared to be cured by surgery
222			_aOPERATIONAL DEFINITION _bOutcomes of radical hysterectomy Refers to the end results of the procedure which can be fully recovery without or with complication plus recurrence
222			_aOPERATIONAL DEFINITION _bLate/ Long term complication Refers to the complication of radical hysterectomy which occurs after 30 days post surgery
222			_aOPERATIONAL DEFINITION _bEarly/ Short term complication Refers to the complication of radical hysterectomy which will occur intra- operative and within 30 days post surgery
222			_aOPERATIONAL DEFINITION _bBladder dysfunction Disease Free Survival Refers to persistent symptoms of urinary tract system after 30 days post surgery Refers to patients without disease during follow up period after surgery
245			_aOutcomes of Patients Undergoing Radical Hysterectomy for Early Cervical Cancer at Bugando Medical Centre, Mwanza Tanzania.
260			_aMwanza, Tanzania: _bCatholic University of Health and Allied Sciences [CUHAS - Bugando] : _c2019
300			_a xi; 34 Pages
300			_aIncludes References and Appendices
520			_aAbstract: Background: Cervical cancer is the fourth common cancer among women worldwide. In developing countries, it remains a major public health burden with more than 85% of all malignancy cases. In Tanzania, it is the leading malignancy in women with approximate 58% of deaths reported annually. Patients presenting in early stage disease can be treated surgically with radical hysterectomy. In Africa limited studies have reported on the outcomes and complications associated with radical hysterectomy. Objective: The aim of the study was to determine the outcomes of patients undergoing radical hysterectomy for early stage of cervical cancer at Bugando Medical Centre, Mwanza – Tanzania. Methodology: This study was a 5-year retrospective and prospective case series involving 62 case files and 16 patients with early stage cervical cancer treated with radical hysterectomy at BMC from January 2014 to May 2019. Case files were obtained at BMC medical records and information were extracted and filled in the data collection tool, and the prospective study involved 16 patient who underwent radical hysterectomy from June 2018 to May 2019, who are still on follow up were recruited in this study. Data were analyzed using STATA version 13 according to the study objectives. Results: During the study period a total of 85 patients underwent radical hysterectomy, seven patients had missing case files, hence only 78 patients were involved in the analysis. Sixty two case files were retrieved retrospectively and 16 patients as prospectively and followed up for a period of 1 month post surgery. The median age was 47.5 [IQR: 42 – 57] years, with the youngest case aged 26 year. Majority of the patients presented with per vaginal bleeding and had more than five children in their life time, 89.5% and 68.0% respectively. Pelvic lymph nodes, parametrial and resected vaginal margins involvement were detected in 12.8%, 10.3% and 23.1% of the patients respectively. Twenty three patients (29.5%) and thirteen patients (16.7%) had intraoperative and postoperative complications respectively. The most intra-operative complication was hemorrhage 14.1%, ureteric injury 7.7%, with operative mortality of 1.3%. The early and late post-operative complication occurred at 12.8% and 9.0%, fistula and bladder dysfunction occurred more frequent at 6.4% in each group respectively. During the study period, the overall survival (OS) rate, disease free survival (DFS) rate and disease recurrence was found to be 92.8%, 81.2% and 11.6% respectively. On fisher’s exact test, tumour size was statistically found to have an association with decrease in survival outcomes and increase in recurrence rate with P – value of 0.019. Conclusions: Radical hysterectomy is still the preferred treatment for patient with early cervical cancer, with favorable survival outcomes and acceptable surgical morbidity.
600			_xObstetrics and Gynecology _948284
700			_aEdgard Ndaboine _922763
700			_aMatovelo, Dismas _920052
942			_2ddc _cMP
999			_c18468 _d18468