000			02700nam a22003257a 4500
001			A. 8359
003			OSt
005			20240305193421.0
008			220510b |||||||| |||| 00| 0 eng d
020			_a0387970304
020			_a 9780387970301
040			_cDLC
082			_a616.152 SHA
100			_a Nasrollah T. Shahidi _937193
245			_aAplastic Anemia and Other Bone Marrow Failure Syndromes
250			_aillustrated
260			_aLondon _bSpringer New York, 1990 Original from the University of Michigan Digitized _c7 Aug 2008
300			_a 236 pages
520			_aDuring the past decade, there have been numerous direct and indirect scientific contributions to both the etiology and therapy of aplastic anemia and related bone marrow failure syndromes. Clinical observations, such as autologous bone marrow recovery after conditioning with immunosup pressive agents for bone marrow transplantation; failure to achieve en graftment in some identical twins without prior immunosuppressive ther apy; and hematologic response to immunosuppressive agents, have led to the concept of immune-mediated etiology of acquired aplastic anemia. Such a concept was further strengthened by laboratory findings, implicat ing the role of activated cytotoxic T lymphocytes and abnormal produc tion of inhibitory lymphokines. The immunologic mechanisms may also apply to the idiosyncratic bone marrow aplasias associated with drugs, toxic chemicals, and viruses. These agents may alter normal cellular recog nition sites by interacting with cellular components and result in loss of self tolerance. Immunologic mechanisms have long been advocated in many other organ failures, and the hemopoietic organ is no exception. It is of interest that parallel clinical and laboratory investigations in juvenile diabetes mellitus type I and in rodent models of this disease have yielded results compatible with the same pathogenic mechanisms. The infiltration of pancreatic islets by activated T lymphocytes, functional and morphological alterations of islet cells upon incubation with lymphokines such as gamma interferon and tumor necrosis factor, and clinical response to cyclosporine are a few examples.
600			_xScience / Life Sciences / Molecular Biology _927008
600			_x Science / Life Sciences / Cell Biology _927913
600			_xMedical / Pediatrics _926838
600			_x Medical / Oncology / General _926891
600			_xMedical / Oncology _929196
600			_x Medical / Immunology _926958
600			_x Medical / Hematology _927137
600			_x Medical / Clinical Medicine _926816
600			_xMedical › Oncology › General _926780
942			_2ddc _cBK
999			_c17892 _d17892