000			03741cam a22004338i 4500
001			20495334
003			OSt
005			20240305193037.0
008			180507t20182018flu 000 0 eng c
010			_a 2018007680
020			_a9781498717403 _q(hardback)
020			_a1498717403 _q(hardback)
020			_z9781351646147 _q(epub)
040			_aOU/DLC _beng _erda _cOU
042			_apcc
050	0	0	_aQR182.2.M36 _bS97 2018
082	0	0	_a616.07/9 _223
245	0	0	_aSystems immunology : _ban introduction to modeling methods for scientists / _cedited by Jayajit Das, Ciriyam Jayaprakash.
263			_a1808
264		1	_aBoca Raton, FL : _bCRC Press, Taylor & Francis Group, _c[2018]
264		4	_c©2018
300			_apages cm.
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
490	1		_aFoundations of biochemistry and biophysics
504			_aIncludes bibliographical references and index.
505	0		_aIntroduction to basic concepts in immunology / Roxana Khazen and Salvatore Valitutti -- Overview of mechanistic modeling: techniques, approximations, and assumptions / Steven M. Abel -- The fundamentals of statistical data analysis / William C.L. Stewart -- Using data to guide model construction: application of principal component analysis and related methods in immunology research / Kathryn Miller-Jensen -- An introduction to rule-based modeling of immune receptor signaling / John A.P. Sekar, James R. Faeder -- Boolean models in immunology / Reinhard Laubenbacher and Elena Dimitrova -- From evolutionary computation to phenotypic spandrels: inverse problem for immune ligand recognition / Paul François and Mathieu Hemery -- Zen and the art of parameter estimation in systems biology / Christopher R. Myers -- Spatial kinetics in immunological modeling / Daniel Coombs and Byron Goldstein -- Analysis and modeling of single cell data / Derya Altintan, Jascha Diemer, and Heinz Koeppl -- Quantifying lymphocyte receptor diversity / Thierry Mora and Aleksandra M. Walczak -- Antigen receptor diversification during immune responses / Miri Michaeli and Ramit Mehr -- Quantitative modeling of mast cell signaling / Lily A. Chylek, David A. Holowka, Barbara A. Baird, and William S. Hlavacek -- Physical models in immune signaling / Jayajit Das -- Population dynamics of host and pathogens / Amber M. Smith, Ruy M. Ribeiro, and Alan S. Perelson -- Viral fitness landscapes: a physical sciences perspective / Gregory R. Hart and Andrew L. Ferguson -- A wish-list for modeling immunological synapses / Michael L. Dustin.
520			_a"New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in making predictions, designing experiments, and elucidating underlying biochemical processes. It begins with an introduction to data analysis, approximations, and assumptions used in model building. Core chapters address models and methods for studying immune responses, with fundamental concepts clearly defined"-- _cProvided by publisher.
650		0	_aImmunology _xMathematical models. _93946
650		0	_aImmunoinformatics. _93947
650		0	_aSystems biology. _93948
700	1		_aDas, Jayajit, _eeditor. _93949
700	1		_aJayaprakash, Ciriyam, _d1952- _eeditor. _93950
830		0	_aFoundations of biochemistry and biophysics. _93951
906			_a7 _bcbc _corignew _d1 _eecip _f20 _gy-gencatlg
942			_2ddc _cBK
999			_c12257 _d12257