Abstract:

Background: Hepatitis B Virus infection continues to be an important public-Health problem. Approximately 2 billion people worldwide have been infected with hepatitis B virus and up to 450 million people are chronic carries, accounting for 55% of global cases of Hepatocellular Carcinoma which 89% are found in endemic regions where tens of millions of news cases of Hepatitis B virus infections occur annually, Causing approximately 2 million deaths per years globally, due to various complication the most common being Hepatocellular Carcinoma. Despite, high magnitude of HBV related HCC in Africa and around the global, there is no clear data available to address the magnitude of this disease in Tanzania as specifically Lake Zone.

Objective: The study aimed to determine the prevalence and outcome of hepatitis B viral among patients with hepatitis B viral among patients with hepatocellular carcinoma at Bugando Medical Centre from 2016 to 2018

Methods: A retrospective hospital based study was done during September to November 2019. During this period different patient’s files both inpatient and outpatient who diagnosed with HCC. The evaluation included demographic data risk factors outcome and vaccination against HBV

Results: In this study the prevalence of HBV among 101 patients with HCC was 31.7% observed mostly among age group of 51-70 years with male to female ratio of 9; 1 in which only 6 patient 13.6% were vaccinated against HBV. The majority of the patient was discharged 61.4% while 38.6% died most of them being male.

Conclusion: The increasing prevalence of HBV related HCC as observed in this study calls for a special effort for solving this problem. The result of this study should put the light on the pattern as well as other factors that may lead to this disease.