Coombs negative hemolytic anemia of unknown origin in pregnancy

By:

SA Dominico

Contributor(s):

Material type: Text

TextPublisher number: Phone: +255 28 298 3384 Fax: +255 28 298 3386 Email: vc@bugando.ac.tz Website: www.bugando.ac.tz Language: English Series: ; J Blood Lymph Volume 2 Issue 103 Publication details: Mwanza, Tanzania: J Blood Lymph & Catholic University of Health and Allied Sciences [CUHAS – Bugando] 2012Description: Pages 2ISSN:

2165-7831

Summary: Abstract Hemolytic anemia is very common during pregnancy especially in malaria endemic areas and it is usually an autoimmune condition. Coombs negative or idiopathic hemolytic disease during pregnancy is very rare and it has not yet been described in sub-Saharan countries. A 34-year-old grand-multiparous woman was referred at our facility at a gestation age of 22 weeks with features of severe anemia in pregnancy, and a history of receiving a blood transfusion (seven units). Several investigations including a Coomb’s test were done. However, there were hardly any derangements, except for initial low hemoglobin. Coombs negative haemolytic anaemia of unknown origin was the inal concluded diagnosis. She was treated with a course of glucorticoids, hematenics and a total of 36 units of blood transfusion. She inally delivered a premature baby at 35 weeks of gestation. She recovered completely during puerperium and was discharged the seventh day postpartum with a hemoglobin of 10g/dl. She was lost to follow up. Coombs Negative Hemolytic Anemia in pregnancy is likely to respond to blood transfusions in conjunction with glucocorticoid therapy

Item type: RESEARCH ARTICLES

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Holdings
Item type	Current library	Collection	Status	Barcode
RESEARCH ARTICLES	MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO	NFIC	-1	RA0381

Total holds: 0

Abstract

Hemolytic anemia is very common during pregnancy especially in malaria endemic areas and it is usually an
autoimmune condition. Coombs negative or idiopathic hemolytic disease during pregnancy is very rare and it has not
yet been described in sub-Saharan countries.

A 34-year-old grand-multiparous woman was referred at our facility at a gestation age of 22 weeks with features
of severe anemia in pregnancy, and a history of receiving a blood transfusion (seven units). Several investigations
including a Coomb’s test were done. However, there were hardly any derangements, except for initial low hemoglobin.
Coombs negative haemolytic anaemia of unknown origin was the inal concluded diagnosis. She was treated with
a course of glucorticoids, hematenics and a total of 36 units of blood transfusion. She inally delivered a premature
baby at 35 weeks of gestation. She recovered completely during puerperium and was discharged the seventh day
postpartum with a hemoglobin of 10g/dl. She was lost to follow up.

Coombs Negative Hemolytic Anemia in pregnancy is likely to respond to blood transfusions in conjunction with
glucocorticoid therapy

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