Contents:

The Clinical Burden of Biliary Disease A Global Perspective

The Healthy Biliary Tree Cellular and Immune Biology

Pathological Features of Biliary Disease in Children and Adults

Animal Models of Biliary Disease Current Approaches and Limitations

The Microbiome and Human Disease A New Organ of Interest in Biliary Disease

Biliary Atresia From Pathology to Treatment

DrugInduced Cholestasis Mechanisms and Importance

Primary Biliary Cholangitis Its Science and Practice

Primary Sclerosing Cholangitis PSC Current Concepts in Biology and Strategies for New Therapy

Cholangiocarcinoma Disease Pathogenesis and New Treatment Paradigms

Gallstone Disease Scientific Understanding and Future Treatment

IgG4Related Sclerosing Cholangitis

Conclusions and Future Opportunities

This book addresses the current understanding of the diagnosis and management of biliary disease across all ages, with emphasis on how the latest advances in clinical science may be integrated into current and future therapies. The coverage is wide ranging, encompassing congenital and acquired conditions including cholestatic syndromes, biliary atresia, drug-induced cholestasis, primary biliary cholangitis/cirrhosis, primary sclerosing cholangitis, cholangiocarcinoma, gallstone disease, and autoimmune sclerosing cholangitis. With contributions from basic and clinical scientists, the relevance of state-of-the-art mechanistic biology to diagnosis, treatment, and future opportunities for drug design is clearly explained. The balance between science and clinical practice will ensure that this book makes a lasting contribution to the field. A broad readership will find the book easy to access and a rich source of information on current best practice and evolving management strategies.