Contents:

Chemical Engineering and Medicine

A Mass Transport Matter

Overview on Polymeric Drug Delivery Systems

Functional Polymers for Drug Delivery

Drug Eluting Stent

This book offers a state-of-the-art overview of controlled drug delivery systems, covering the most important innovative applications. The principles of controlled drug release and the mechanisms involved in controlled release are clearly explained. The various existing polymeric drug delivery systems are reviewed, and new frontiers in material design are examined in detail, covering a wide range of polymer modification techniques. The concluding chapter is a case study focusing on use of a drug-eluting stent. The book is designed to provide the reader with a complete understanding of the mechanisms and design of controlled drug delivery systems, and to this end includes numerous step-by-step tutorials. It illustrates how chemical engineers can advance medical care by designing polymeric delivery systems that achieve either temporal or spatial control of drug delivery and thus ensure more effective therapy that eliminates the potential for both under- and overdosing. Common terms and phrases; acid adinazolam agarose Anseth applications approach artery biocompatibility biodegradable biomaterials biomedical bonds bone cell chemical engineering chemistry considered constant controlled drug delivery Controlled Release copolymer cross-linked ð Þ D0 ¼ degradation depends Diels-Alder Diels-Alder reaction dienophile diffusion coefficient drug concentration drug delivery drug delivery systems drug release drug-eluting stent equation equilibrium extracellular Fatin-Rouge Fickian functional polymers groups hydrodynamic radius hydrogels hydrophilic implants increasing ion diffusion Journal kinetics ligands Macromolecules macromonomers materials matrix mechanical membrane Milano molecular weight molecules monomer Moreover nanoparticles parameters Peppas peptides Perale permeability physical Politecnico di Milano polymer chains polymer concentration Polymer Science polymeric post-polymerization modification proliferation properties protein release profile represent Reproduced with permission restenosis Rossi scaffolds self-diffusion coefficient Semi-dilute polymer solutions Shoichet small-sized diffusants solute diffusion solvent spinal cord injury strategies studied swelling swollen synthetic polymers temperature thiol thiol-ene reaction tissue engineering transport volume fraction