Contents:

1 Introduction

2 Physiologic Changes During Pregnancy

3 Impact of Pregnancy on Maternal Pharmacokinetics of Medications

4 Medications and the Breastfeeding Mother

5 Fetal Drug Therapy

an Evolving Therapeutic Concept

7 What is Sufficient Evidence to Justify a Multicenter Phase 3 Randomized Controlled Trial in Obstetrics?

8 Ethics of Clinical Pharmacology Research in Pregnancy

15 Substance Use Disorders

16 Diabetes in Pregnancy

17 Cardiovascular Medications in Pregnancy

18 Antidepressants in Pregnancy

19 Uterine Contraction Agents and Tocolytics

20 Antenatal Thyroid Disease and Pharmacotherapy in Pregnancy

21 Dermatological Medications and Local Therapeutics

22 Vitamins Minerals Trace Elements and Dietary Supplements


9 Pharmacogenomics in Pregnancy

10 Analgesics and AntiInflammatory General and Local Anesthetics and Muscle Relaxants

11 The Management of Asthma During Pregnancy

12 Updated Guidelines for the Management of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum

13 Clinical Pharmacology of AntiInfectives During Pregnancy

14 Chemotherapy in Pregnancy

23 Herbs and Alternative Remedies

24 Envenomations and Antivenoms During Pregnancy

25 Gastrointestinal Disorders

Index
Clinical Pharmacology During Pregnancy

Clinical Pharmacology During Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy.

The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are covered, as are research issues, including clinical trial design and ethical considerations.

Uses an evidence-based approach for therapeutics during pregnancy
Includes a summary of specific medications by indication with up-to-date information on dosing and efficacy in pregnancy for the given indication Common terms and phrases: acid activity addiction administration adverse agents alcohol anesthesia anesthetic antidepressants antivenom associated asthma atenolol birth weight breast cancer breast milk breastfeeding buprenorphine calcium changes clearance Clin Pharmacol clinical clonidine concentrations congenital corticosteroids cross the placenta decreased delivery depression digoxin disease disorders dose drug efficacy envenomation enzymes excreted exposure FDA category fetal fetus gestational diabetes glucose glyburide Gynecol half-life hemodynamic hepatic human hypertension hypothyroidism increased risk indomethacin infants infections inhibitors insulin intravenous lactation malformations maternal medications Metab metabolism metformin methadone mother nancy neonatal nifedipine non-pregnant ObstetGynecol Obstetrics opioid oral outcomes perinatal pharmacodynamic pharmacokinetics pharmacological placenta plasma postpartum potential preeclampsia preg pregnancy category pregnant patients pregnant women prenatal preterm labor protein binding receptor recommended renal reported result safety serum side effects symptoms syndrome teratogenic therapeutic therapy third trimester thyroid tion tocolysis tocolytic toxicity treat treatment trials trimester trimester of pregnancy urine uterine vitamin weeks