Contents:

Biochemical investigations in clinical

Water sodium and potassium

Hydrogen ion homoeostasis and blood

The kidneys

Theliver

The gastrointestinal tract

The hypothalamus and the pituitary gland

The adrenal glands Chapter 9 The thyroid gland

Disorders of carbohydrate metabolism

Calcium phosphate and magnesium

Plasma proteins and enzymes

Lipids lipoproteins andcardiovascular disease Chapter 15The locomotor and nervous systems

Inherited metabolic diseases Chapter 17 Disorders of haemoproteins porphyrins and iron Chapter 18 Metabolic aspects of malignant disease Chapter ...

Clinical chemistryat the extremes of age Appendix Adult reference ranges

Index

Clinical Chemistry considers what happens to the body’s chemistry when affected by disease. Each chapter covers the relevant basic science and effectively applies this to clinical practice. It includes discussion on diagnostic techniques and patient management and makes regular use of case histories to emphasise clinical relevance, summarise chapter key points and to provide a useful starting point for examination revision.

The clear and engaging writing style appreciated by generations of readers has been retained in this new (eighth) edition, while the content has been thoroughly updated throughout. The approach and scope of this trusted text makes it ideal for integrated medical curricula for medical training and for students and practitioners of clinical and biomedical science. Additional (electronic) self-assessment material, completes this superb learning package.

Bonus self-assessment materials - interactive clinical cases and two tier level MCQs (‘standard’ and ‘advanced’)
New introductory chapter on basic biochemistry - including solutions, solutes, ionisation, pH, buffers, amino acids, peptides and proteins, enzyme activity, including kinetic properties, DNA structure
‘Light bulb’ sections give practical advice and clarify difficult concepts or potential pitfalls
Updated references to core guidelines (UK and international) reflect latest best practice Common terms and phrases: abnormal acid acidosis ACTH activity acute adrenal albumin aldosterone alkalosis amino androgens andthe bicarbonate bilirubin biochemical bone calcitriol calcium canbe carbon cause cells cholesterol chronic clinical features condition cortisol creatinine Cushing’s syndrome decreased deficiency depletion detection develop diabetes diagnosis disorders diuretics drugs effect endocrine enzyme excess excretion factors failure Figure fluid frequently function glomerular glucose gonadotrophin haemochromatosis haemoglobin hepatic homoeostasis hydrogen ion hypercalcaemia hypercholesterolaemia hyperlipidaemia hypertension hyperuricaemia hypoglycaemia hyponatraemia hypothyroidism impaired increased inherited metabolic inhibits insulin intake intestinal inthe intracellular intravenous Investigations Serum kidneys laboratory lipoprotein liver disease malabsorption measurement metabolic mmol/L monitoring muscle non-respiratory normal occur ofthe osmolality pancreatic paraprotein patients phosphate pituitary plasma plasma concentration porphyria potassium pregnancy present protein proteinuria reabsorption receptor renal respiratory response result risk screening secretion sodium specific stimulates synthesis testosterone thyroid hormones tissue tothe treatment triglyceride tubular tumour urea urinary urine usually vasopressin