Abstract:

Introduction: Sickle cell disease is an autosomal recessive disorder resulting from a mutation of a beta globulin gene consequently causing red blood cell to be deformed into a sickle shape. Kidney injury in SCD, referred to as sickle cell nephropathy (SCN). Sickle cell nephropathy results from recurrent renal Vaso occlusion, ischemic injury and loss of nephron mass. Renal failure develops in up to 18% of adult patients with sickle cell disease (SCD). Ssickle cell nephropathy (SCN), is a common, under recognized complication. There is paucity of data on sickle nephropathy in our locality and associated factors. This study intends to highlight this problem and help to tailor sickle cell treatment guidelines.

Aim: To determine the factors associated with prevalence of proteinuria among adults’ sickle cell disease patients seen at Bugando Medical Centre?

Methodology: This was Prospective Cross-sectional study, where all adult sickle cell disease patients attending clinic will be screened using urine dipstick, to check for the presence of proteins. Patient electronic files was used to extract patients’ demographics and clinical presentations.

Results: 50 participants were enrolled in this study with a median[IQR] age of 18[15-21] and majority were female 33(66%) with a common symptoms of pain and acute chest syndrome 45(90%) and 42(84%) respectively .majority 41(82%) had history of blood transfusion in the past two years. The prevalance of proteinuria was 7/50(14%) and the associated factors was swelling limb.

Conclusion: This study observed that the prevalence of the proteinuria was 14% and associated factors was swelling limb.