Clinical presentation and outcome of multiple myeloma patients at Bugando Medical Centre, Mwanza, Tanzania
Material type:
TextPublisher number: Phone: +255 28 298 3384 Fax: +255 28 298 3386 Email: vc@bugando.ac.tz Website: www.bugando.ac.tz Language: English Language: Kiswahili Publication details: Mwanza, Tanzania : Catholic University of Health and Allied Sciences [CUHAS – Bugando] ©26.08.2021Description: vii; 19 Pages; Includes References and AppendicesSubject(s): Summary: Abstract:
Aim: Late presentation and occurrence of complications adversely affects survival. This study aim at identifying initial clinical and basic laboratory features of multiple myeloma (MM), which will aid the physician to entertain a high index of suspicion and therefore target his investigations in order to prevent late presentation and reduce the incidence of complications.
Material and methodology: A retrospective analysis of 38 MM patients diagnosed at BMC Tanzania was done. Information on the clinical presentation, laboratory, and radiological data as well as response to the mode of treatment was and analyzed.
Results: The median age at diagnosis was 56 years. Males (78.9%) and females (21.1%). The mean duration of symptoms at presentation was 6.9 months. Clinical features at presentation were bone pains (81.7%), and anemia (44.6%), lytic lesions in (36.8%) while pathological fractures in 21.1%) nephropathy in 18.7%.
Conclusion: Presence of bone pain and anemia in elderly patients should alert the clinician to investigate along the lines of MM. Majority of patients have osteolytic lesions on X-ray and pathological fractures and benefit from melphalan based combinations in situations where facilities for transplant are not available.
| Item type | Current library | Collection | Status | Barcode | |
|---|---|---|---|---|---|
| UNDERGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | 1 | UD2455 |
Abstract:
Aim: Late presentation and occurrence of complications adversely affects survival. This study aim at identifying initial clinical and basic laboratory features of multiple myeloma (MM), which will aid the physician to entertain a high index of suspicion and therefore target his investigations in order to prevent late presentation and reduce the incidence of complications.
Material and methodology: A retrospective analysis of 38 MM patients diagnosed at BMC Tanzania was done. Information on the clinical presentation, laboratory, and radiological data as well as response to the mode of treatment was and analyzed.
Results: The median age at diagnosis was 56 years. Males (78.9%) and females (21.1%). The mean duration of symptoms at presentation was 6.9 months. Clinical features at presentation were bone pains (81.7%), and anemia (44.6%), lytic lesions in (36.8%) while pathological fractures in 21.1%) nephropathy in 18.7%.
Conclusion: Presence of bone pain and anemia in elderly patients should alert the clinician to investigate along the lines of MM. Majority of patients have osteolytic lesions on X-ray and pathological fractures and benefit from melphalan based combinations in situations where facilities for transplant are not available.
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