Rubella Seroprevalence and Associated Factors Among Infants With Features of the Congenital Rubella Syndrome Attending at Bugando Medical Centre, Mwanza Tanzania
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TextPublisher number: Wurzburg Road 35, BMC Premises, Post Code: 33102: P. O Box 1464, Mwanza – Tanzania: Phone: +255 28 298 3384: Fax: +255 28 298 3386: Email: vc@bugando.ac.tz :www.bugando.ac.tzLanguage: English Publication details: Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS - Bugando] : 2018Description: xiv; 48 Pages; Includes References and AppendicesSubject(s): Summary: Abstract:
Background: Congenital Rubella Syndrome (CRS) affect millions of children globally and is one of the cause of infant mortality and lifelong disability due to severe birth defects. It remains a public health problem in a significant number of resource limited countries. Global health experts encourage use of rubella vaccination, with the primary aim of preventing CRS. This study aimed to determine prevalence of probable CRS cases, rubella antibodies and associated factors among infants suspected to have CRS.
Methods: This was a cross sectional hospital based study which included 174 infants aged ≤ 12 months with clinical features of CRS. The study was conducted between September 2017 and March 2018 at Bugando Medical Centre. Social demographic and other relevant information were gathered using structured using structured questionnaire. Screening for clinical signs and symptoms suggestive of CRS were performed. Blood samples were collected and sera were used to test for specific Rubella IgM and IgG antibodies using indirect enzymes-linked immunosorbent assay (ELISA).
Results: The median age of enrolled children was 5.5[1 – 24] weeks; of these 83 (47.7%) were neonates. The majority 114(65.5%) of these infants were infants were from urban areas and only 13.2% had received MR vaccine. Out of 174 infants investigated, 111 (63.8%, 95%CI: 56.6-70.9) were IgG Rubella seropositive whereas none was IgM Rubella seropositive. Twenty six (14.9%) had probable CRS. On univariate analysis being neonates (OR 2.3; 95% CI: 1.2 – 4.3; p=0.012) was significantly associated with Rubella IgG seropositivity, whereas history of abortion had borderline significance (OR 2.5; 95%CI 0.9 – 6.5; p=0.063. By multivariate logistic regression analysis only being neonate independently predicted rubella IgG seropositivity (OR 2.3; 95% CI 1.2 – 4.4; p=0.012).
Conclusion: A Significant proportion children (<12 months) with suspected CRS are IgG seropositive which is predicted by being a neonate (0.4 weeks); this indicates high maternal seroprevalence. In addition, a significant proportion of infants with suspected CRS can be grouped as probable CRS which are more likely to be Rubella IgG seropositive.
| Item type | Current library | Collection | Status | Barcode | |
|---|---|---|---|---|---|
| POSTGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | 1 | PD0278 |
Abstract:
Background: Congenital Rubella Syndrome (CRS) affect millions of children globally and is one of the cause of infant mortality and lifelong disability due to severe birth defects. It remains a public health problem in a significant number of resource limited countries. Global health experts encourage use of rubella vaccination, with the primary aim of preventing CRS. This study aimed to determine prevalence of probable CRS cases, rubella antibodies and associated factors among infants suspected to have CRS.
Methods: This was a cross sectional hospital based study which included 174 infants aged ≤ 12 months with clinical features of CRS. The study was conducted between September 2017 and March 2018 at Bugando Medical Centre. Social demographic and other relevant information were gathered using structured using structured questionnaire. Screening for clinical signs and symptoms suggestive of CRS were performed. Blood samples were collected and sera were used to test for specific Rubella IgM and IgG antibodies using indirect enzymes-linked immunosorbent assay (ELISA).
Results: The median age of enrolled children was 5.5[1 – 24] weeks; of these 83 (47.7%) were neonates. The majority 114(65.5%) of these infants were infants were from urban areas and only 13.2% had received MR vaccine. Out of 174 infants investigated, 111 (63.8%, 95%CI: 56.6-70.9) were IgG Rubella seropositive whereas none was IgM Rubella seropositive. Twenty six (14.9%) had probable CRS. On univariate analysis being neonates (OR 2.3; 95% CI: 1.2 – 4.3; p=0.012) was significantly associated with Rubella IgG seropositivity, whereas history of abortion had borderline significance (OR 2.5; 95%CI 0.9 – 6.5; p=0.063. By multivariate logistic regression analysis only being neonate independently predicted rubella IgG seropositivity (OR 2.3; 95% CI 1.2 – 4.4; p=0.012).
Conclusion: A Significant proportion children (<12 months) with suspected CRS are IgG seropositive which is predicted by being a neonate (0.4 weeks); this indicates high maternal seroprevalence. In addition, a significant proportion of infants with suspected CRS can be grouped as probable CRS which are more likely to be Rubella IgG seropositive.
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