Seroprevalence and Factors Associated with Zika and Dengue Virus Infections Among Symptomatic Pregnant Women Attending Antenatal Clinics in Rural and Urban Areas of Mwanza Tanzania
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TextPublisher number: Wurzburg Road 35, BMC Premises, Post Code: 33102: P. O Box 1464, Mwanza – Tanzania: Phone: +255 28 298 3384: Fax: +255 28 298 3386: Email: vc@bugando.ac.tz :www.bugando.ac.tzLanguage: English Publication details: Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS - Bugando] : 2018Description: xiii; 43 Pages; Includes References and AppendicesSubject(s): Summary: ABSTRACT:
Background: Zika and Dengue viruses are vector borne viral infections of public health importance in tropical and subtropical countries and have been associated with adverse pregnancy outcomes. Infection with these viruses during pregnancy may results into adverse pregnancy outcomes. Zika virus also has been associated with complications such as Guillen Barre Syndrome, myelitis and meningoencephalitis. Despite increasing reports of Zika and Dengue virus related complications during pregnancy in most of Latin America countries, there is scarcity of data regarding the magnitude of these viruses in most African countries where they are considered to be endemic.
Objectives: This study aimed at determining the seroprevalence and factors associated with Zika and Dengue viruses among symptomatic pregnant women attending antenatal clinics in rural and urban areas of Mwanza, Tanzania
Methodology: This was hospital based cross sectional study with a follow up component involving 171 pregnant women with signs and symptoms of these viruses in the current pregnancy which was, conducted July 2017 to April 2018. Sera were collected and used for detection of Zika and Dengue viruses specific antibodies (IgM and IgG) using rapid immunochromatographic test as per manufacturer’s instructions (TELL ME FAST, Canada) followed by multiplex polymerase chain reaction (PCR).
Results: The median age of enrolled women was 24 [IQR: 21-30] years with the median gestation age of 25[IQR 20-32] weeks. Seroprevalence of Zika virus was found to be 5(2.9%) while that of Dengue virus was 12(7.0%). The overall seroprevalence (Dengue/Zika virus) was 16 (9.4%) (95% CI: 5.0-13.7). The odds of being Zika/Dengue seropositive were significantly high among women with advanced age (OR=1.16, 95% CI: 1.02 – 1.32, p=0.024) and those residing in rural areas (OR=5.03, 95% CI: 1.04-24.29, p=0.044) compared to their counterparts.
Conclusion and recommendations: About 9% of pregnant women in Mwanza are seropositive to Zika/Dengue viruses which are predicted by having advanced age and residing in rural areas. This calls for the need for attending doctors/nurses to put much emphasis on mosquito control measures to reduce the transmission of this infection especially in rural settings well as inclusion of screening of these infections for high risk women.
| Item type | Current library | Collection | Status | Barcode | |
|---|---|---|---|---|---|
| POSTGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | 1 | PD0244 |
ABSTRACT:
Background: Zika and Dengue viruses are vector borne viral infections of public health importance in tropical and subtropical countries and have been associated with adverse pregnancy outcomes. Infection with these viruses during pregnancy may results into adverse pregnancy outcomes. Zika virus also has been associated with complications such as Guillen Barre Syndrome, myelitis and meningoencephalitis. Despite increasing reports of Zika and Dengue virus related complications during pregnancy in most of Latin America countries, there is scarcity of data regarding the magnitude of these viruses in most African countries where they are considered to be endemic.
Objectives: This study aimed at determining the seroprevalence and factors associated with Zika and Dengue viruses among symptomatic pregnant women attending antenatal clinics in rural and urban areas of Mwanza, Tanzania
Methodology: This was hospital based cross sectional study with a follow up component involving 171 pregnant women with signs and symptoms of these viruses in the current pregnancy which was, conducted July 2017 to April 2018. Sera were collected and used for detection of Zika and Dengue viruses specific antibodies (IgM and IgG) using rapid immunochromatographic test as per manufacturer’s instructions (TELL ME FAST, Canada) followed by multiplex polymerase chain reaction (PCR).
Results: The median age of enrolled women was 24 [IQR: 21-30] years with the median gestation age of 25[IQR 20-32] weeks. Seroprevalence of Zika virus was found to be 5(2.9%) while that of Dengue virus was 12(7.0%). The overall seroprevalence (Dengue/Zika virus) was 16 (9.4%) (95% CI: 5.0-13.7). The odds of being Zika/Dengue seropositive were significantly high among women with advanced age (OR=1.16, 95% CI: 1.02 – 1.32, p=0.024) and those residing in rural areas (OR=5.03, 95% CI: 1.04-24.29, p=0.044) compared to their counterparts.
Conclusion and recommendations: About 9% of pregnant women in Mwanza are seropositive to Zika/Dengue viruses which are predicted by having advanced age and residing in rural areas. This calls for the need for attending doctors/nurses to put much emphasis on mosquito control measures to reduce the transmission of this infection especially in rural settings well as inclusion of screening of these infections for high risk women.
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