Abstract:

Background: Escherichia coli (E. coli) is a bacterium that colonises the gastrointestinal tract of both human and animals. Effective treatment against this organism depends on several antibiotics with guidance through culture and sensitivity. Treatment is increasingly complicated due to the ability of these agents to develop resistance strains easily against antimicrobial. Multidrug-resistant E.coli often express extended spectrum beta-lactamases (ESBLs) that favour increased resistance to broad-spectrum beta lactam antibiotics.

Methodology: A cross sectional study was conducted of sample size of 42 patients at Nyamagana District hospital, data collection was done through an online program of Epicollect stool samples were also collected, stored and processed at CUHAS laboratory, analysis was done by using an Microsoft excel program.

Results: following culture results 13 (45%) samples had a positive stool culture for gram negative bacteria producing extended spectrum beta lactamase (ESBL). E. coli was a predominant microorganisms 13 (45%) and 6 (21%) samples had no bacteria growth (NBG), remaining 10 (34%) samples had multiple bacterial growth including a Klebsiela pneumonia.

Conclusion: High antibiotics consumption at Nyamagana District hospital which correlates with high rate of ESBL producing E. coli which were found following culture of stool sample, there is direct linkage of high antibiotics consumption and production of ESBL producing E. coli, also some other samples had not reported history of antibiotic consumption but has managed to produce culture growth for ESBL producing E. coli suggesting that not only antibiotic consumption accounts for production of resistant strains of organisms.