Evaluation of Potential Drug-Drug Interaction on Medications Prescribed to Hypertensive Patients at Bugando Medical Centre.
Material type:
TextPublication details: Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS – Bugando] Phone: +255 28 298 3384 : Fax: +255 28 298 3386: Email: vc@bugando.ac.tz : Website: www.bugando.ac.tz : ©2019Description: xi; 20 Pages; Includes Refferences and AppendicesSubject(s): Summary: Abstract:
Background: Hypertensive patients are particularly at risk of drug-drug interactions resulting from the concomitant use of multiple drugs to control their blood pressure. Advanced age and presence of comorbidities are likely to contribute to use of many drugs, further increasing this risk.
Methodology: A retrospective cross sectional study was conducted among hypertensive patients. The study was conducted at internal medicines department in BMC in Mwanza. The sample (125) was randomly selected based on data files of hypertensive patients (inpatients’ files) with or without comorbidities given more than one medication in internal medicine department at BMC and data was filled in data collection tool.
Results and Discussion: The most prescribed anti-hypertensive drugs were Nifedipine which appeared in 53 prescriptions (19.1%), followed by furosemide 34 prescriptions (12.3%), and followed by carvediol (9.7%), losartan H (6.9%), captopril (6.9%), spironolactone (6.9%) and hydralazine (6.9%). Medications which were less prescribed were Irbesartan (0.4%), Indapamide (0.4%) and Prazocin (0.4%). On the matter of prevalence of PDDI, among 125 prescriptions, 105 prescriptions had interactions while 20 prescriptions had no interactions. Among 105 prescriptions with interactions, 57 prescriptions had 1-2 interactions, 28 prescriptions had 3-4 interactions and 20 prescriptions had >4 interactions.
According to the interactions formed, interactions were classified basing on their severity. Major interactions which interactions which had severe side effects were found to be 7. Moderate interactions which had some side effects not as serious as major but should be taken into considerations were 248. Minor interactions which had less side effects were 48. Some side effects which would possibly appear due to these drug interactions are increased risk of hypotension, hyperkalemia, increased serum level of another drug, decreased serum level of another drug.
Conclusion: The comorbidities, advanced age, and polypharmacy are the important factors determining the drug-drug interactions.
| Item type | Current library | Collection | Status | Barcode | |
|---|---|---|---|---|---|
| UNDERGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | 1 | UD0891 |
Abstract:
Background: Hypertensive patients are particularly at risk of drug-drug interactions resulting from the concomitant use of multiple drugs to control their blood pressure. Advanced age and presence of comorbidities are likely to contribute to use of many drugs, further increasing this risk.
Methodology: A retrospective cross sectional study was conducted among hypertensive patients. The study was conducted at internal medicines department in BMC in Mwanza. The sample (125) was randomly selected based on data files of hypertensive patients (inpatients’ files) with or without comorbidities given more than one medication in internal medicine department at BMC and data was filled in data collection tool.
Results and Discussion: The most prescribed anti-hypertensive drugs were Nifedipine which appeared in 53 prescriptions (19.1%), followed by furosemide 34 prescriptions (12.3%), and followed by carvediol (9.7%), losartan H (6.9%), captopril (6.9%), spironolactone (6.9%) and hydralazine (6.9%). Medications which were less prescribed were Irbesartan (0.4%), Indapamide (0.4%) and Prazocin (0.4%). On the matter of prevalence of PDDI, among 125 prescriptions, 105 prescriptions had interactions while 20 prescriptions had no interactions. Among 105 prescriptions with interactions, 57 prescriptions had 1-2 interactions, 28 prescriptions had 3-4 interactions and 20 prescriptions had >4 interactions.
According to the interactions formed, interactions were classified basing on their severity. Major interactions which interactions which had severe side effects were found to be 7. Moderate interactions which had some side effects not as serious as major but should be taken into considerations were 248. Minor interactions which had less side effects were 48. Some side effects which would possibly appear due to these drug interactions are increased risk of hypotension, hyperkalemia, increased serum level of another drug, decreased serum level of another drug.
Conclusion: The comorbidities, advanced age, and polypharmacy are the important factors determining the drug-drug interactions.
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