Hematological Indices Among Paediatric Cancer Patients Undergoing Chemotherapy at Bugando Medical Centre in Mwanza, Tanzania.
Material type:
TextPublisher number: Wurzburg Road 35, BMC Premises, Post Code: 33102: P. O. Box 1464, Mwanza – Tanzania: Phone: +255 28 298 3384: Fax: +255 28 298 3386: Email: vc@bugando.ac.tz : www.bugando.ac.tzLanguage: English Language: Kiswahili Publication details: Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS – Bugando] : ©2019Description: viii; 27 Pages; Includes ReferencesSubject(s): Summary: Abstract:
Background: Chemotherapy is useful in treating malignant diseases. Among pediatric cancer patients in Tanzania, no published data explains their baseline hematological indices and how such indices change over time while on chemotherapy treatment.
Objective: This study aimed to determine the baseline hematological indices among pediatric cancer patients attending Bugando medical centre (BMC) and how such indices change while on chemotherapy.
Methodology: A combined retrospective- prospective cross-sectional study was conducted at Bugando medical centre from January to August 2019. Sixty nine new pediatric cancer cases and 52 healthy controls were tested for baseline hematological indices, then 30/69 cases were prospectively followed after only one cycle of chemotherapy to obtain similar indices using the DH 76 auto hematology analyzer. Data was analyzed using Microsoft Excel.
Results: Participants were aged between 0-18 years old. Out of 52 controls, 28 (53.8%) were female while among cases, 39 (56.5%) were female. The most prevalent cancer type was Wilm’s tumor followed by retinoblastoma. At baseline, control’s mean (SD) Hb and MCV were significantly lower while total WBC count and ANC indices were comparably higher than among cases with the most effect on the highest age group (11.6 (2.1) g/dl, 75 (10.4) µm3 , 3.48 (2.2) x 109 /1 and 8.37 (4.2) x 109/1 versus 9.7 (3.4) g/dl, 69.5 (11) µm3, 5.6 (5.65) x 109/1 and 11.36 (9.22) x 109/1 respectively (p = 0.0072, 0.0091, 0.013 and 0.032 respectively). Microcytosis, leukocytosis, thrombopenia, thrombocytosis and moderate to severe anemia were more prevalent in cases than in controls. After one cycle of chemotherapy, only total WBC count significantly decreased compared to other indices (9.76 (6.65) x 109/1 to 6.67 (3.76) x 109/1, p=0.03) with vincristine and cyclophosphamide based regimens significantly decreasing neutrophils and total WBC respectively (5.02 (34) x 109/1 to 3.16 (2.61) x 109/1, p =0.04 and 11.73 (4.9) x 109/1 to 5.8 (3.66) x 109/1. P =0.03 respectively.
Conclusion: Haematological outcomes were poor among cancer patients compared with healthy controls. Chemotherapy use were significantly associated with a reduction of total leukocyte count, with Vincristine and cyclophosphamide based regimens increasing this effect.
| Item type | Current library | Collection | Status | Barcode | |
|---|---|---|---|---|---|
| UNDERGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | 1 | UD0839 |
Abstract:
Background: Chemotherapy is useful in treating malignant diseases. Among pediatric cancer patients in Tanzania, no published data explains their baseline hematological indices and how such indices change over time while on chemotherapy treatment.
Objective: This study aimed to determine the baseline hematological indices among pediatric cancer patients attending Bugando medical centre (BMC) and how such indices change while on chemotherapy.
Methodology: A combined retrospective- prospective cross-sectional study was conducted at Bugando medical centre from January to August 2019. Sixty nine new pediatric cancer cases and 52 healthy controls were tested for baseline hematological indices, then 30/69 cases were prospectively followed after only one cycle of chemotherapy to obtain similar indices using the DH 76 auto hematology analyzer. Data was analyzed using Microsoft Excel.
Results: Participants were aged between 0-18 years old. Out of 52 controls, 28 (53.8%) were female while among cases, 39 (56.5%) were female. The most prevalent cancer type was Wilm’s tumor followed by retinoblastoma. At baseline, control’s mean (SD) Hb and MCV were significantly lower while total WBC count and ANC indices were comparably higher than among cases with the most effect on the highest age group (11.6 (2.1) g/dl, 75 (10.4) µm3 , 3.48 (2.2) x 109 /1 and 8.37 (4.2) x 109/1 versus 9.7 (3.4) g/dl, 69.5 (11) µm3, 5.6 (5.65) x 109/1 and 11.36 (9.22) x 109/1 respectively (p = 0.0072, 0.0091, 0.013 and 0.032 respectively). Microcytosis, leukocytosis, thrombopenia, thrombocytosis and moderate to severe anemia were more prevalent in cases than in controls. After one cycle of chemotherapy, only total WBC count significantly decreased compared to other indices (9.76 (6.65) x 109/1 to 6.67 (3.76) x 109/1, p=0.03) with vincristine and cyclophosphamide based regimens significantly decreasing neutrophils and total WBC respectively (5.02 (34) x 109/1 to 3.16 (2.61) x 109/1, p =0.04 and 11.73 (4.9) x 109/1 to 5.8 (3.66) x 109/1. P =0.03 respectively.
Conclusion: Haematological outcomes were poor among cancer patients compared with healthy controls. Chemotherapy use were significantly associated with a reduction of total leukocyte count, with Vincristine and cyclophosphamide based regimens increasing this effect.
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