Abstract:

Background: Multidrug resistant (MDR) bacteria are one of the most important current threats to public health. Typically, MDR bacteria are associated with nosocomial infections like UTIs. Despite the emphasis done by the government under the ministry of health, in community awareness to MDR and its association with increase mortality, cost of treatment and hospital stay. The magnitude of MDR gram negative bacteria colonizing the gastrointestinal tract among clinically diagnosed UTIs patients in Sengerema is unknown.

Objective: This study at determining the prevalence and factors associated with gastrointestinal carriage of multidrug resistant bacteria among urinary tract infections patients at Sengerema district hospital.

Methods: A prospective cross sectional both hospital and community based study enrolling 212 patients attending at Sengerema Designated District Hospital was conducted from April, 2019 to July, 2019. Data including socio-demographic data were collected using a well pre tested made questionnaire. Stool sample was aseptically collected, cultured, biochemical identification tests and antibiotic susceptibility tests were done. Data analysis was done using STATA version 13.

Results: After primary isolation on MCA containing cefotaxime, out of 266 screened 128 (48.12%) were cefotaxime resistant. On subsequent subculture of 128 (48.12%) cefotaxime resistant patients, 29 (22.26%) were also ciprofloxacin resistant, 17 (13.28%) were gentamicin resistant and 8 (6.25%) were found to be MDR bacteria.

Conclusion and Recommendation: This study has found high prevalence of cefotaxime, ciprofloxacin and gentamicin resistance in the fecal carriage among UTIs symptomatic patients attending at SDDH. The results in this study underscore the need to improve microbiological diagnostic facilities and antibiotic resistance surveillance in resource-poor settings to be able to promptly revise antibiotic regimens to tackle resistance development.