Viral Load Test Outcome and Predictors of Virologic Failure Among Adults on Highly Active Antiretroviral Therapy at Bugando Medical Centre.
Material type:
TextPublisher number: Wurzburg Road 35, BMC Premises, Post Code: 33102: P. O Box 1464, Mwanza – Tanzania: Phone: +255 28 298 3384: Fax: +255 28 298 3386: Email: vc@bugando.ac.tz : www.bugando.ac.tzLanguage: English Language: Kiswahili Publication details: Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS – Bugando] : ©2016Description: x; 25 Pages; Includes ReferencesSubject(s): Summary: Abstract:
Background: In Tanzania, access to highly active antiretroviral (HAART) start on massive scale 2004, however, limited availability of monitoring tools for measuring response to antiretroviral therapy remain primary challenge. HVL monitoring through NACP started in May 2015 and Mwanza was among the pilot regions for the program whereby Bugando medical centre was the selected laboratory for HVL testing. The overall objectives of HVL testing included the following; (i) to confirm suspected clinical or immunologic failure, (ii) to maximize the clinical benefits of first-line therapy (iii) to reduce irrational switching to second-line therapy. Clinical and immunological criteria are associated with limitations in monitoring ART response follow up and detection of treatment failure. The use of only clinical evaluation and measurement of CD4 cause the unnecessary change of first line drugs to second line but there is limited data to support the importance of viral load monitoring over CD4 and /or clinical monitoring among individual with HIV receiving ART.
Methodology: A retrospective cross sectional study of patients who were receiving HAART and suspected to have treatment failure at Bugando medical centre was conducted, 229 adults (from May 2015 to April 2016) were randomly selected. Information from files paying attention to the specific variables of interest were collected, data entry and analysis was done by using SPSS software version 20.
Results: We enrolled 229 adults suspected to have treatment failure; the median age was 45 years. 137 (59.8%) were females and 92 (40.2%) were males. Out of 229 patients 129 (56.3%) had undetectable viral load, 30 (13.1%) viral load less than 1000 copies and only 70 (30.6%) had more than 1000 copies, out of these 70 only 57 their viral load persist to be higher thus virologic failure among adult who suspected failing treatment is 24.5% the peak age group where virologic failure is high was 41-60 years (p value <0.1) and 55 patients (98.2%) had virological failure compared to 158 (91.3%) who shows no failure (p value <0.05).
Conclusion: This study had demonstrated poor performance of clinical and immunologic criteria in detecting virologic failure among adults at Bugando medical centre.
| Item type | Current library | Collection | Status | Barcode | |
|---|---|---|---|---|---|
| UNDERGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | 1 | UD0509 |
Abstract:
Background: In Tanzania, access to highly active antiretroviral (HAART) start on massive scale 2004, however, limited availability of monitoring tools for measuring response to antiretroviral therapy remain primary challenge. HVL monitoring through NACP started in May 2015 and Mwanza was among the pilot regions for the program whereby Bugando medical centre was the selected laboratory for HVL testing. The overall objectives of HVL testing included the following; (i) to confirm suspected clinical or immunologic failure, (ii) to maximize the clinical benefits of first-line therapy (iii) to reduce irrational switching to second-line therapy. Clinical and immunological criteria are associated with limitations in monitoring ART response follow up and detection of treatment failure. The use of only clinical evaluation and measurement of CD4 cause the unnecessary change of first line drugs to second line but there is limited data to support the importance of viral load monitoring over CD4 and /or clinical monitoring among individual with HIV receiving ART.
Methodology: A retrospective cross sectional study of patients who were receiving HAART and suspected to have treatment failure at Bugando medical centre was conducted, 229 adults (from May 2015 to April 2016) were randomly selected. Information from files paying attention to the specific variables of interest were collected, data entry and analysis was done by using SPSS software version 20.
Results: We enrolled 229 adults suspected to have treatment failure; the median age was 45 years. 137 (59.8%) were females and 92 (40.2%) were males. Out of 229 patients 129 (56.3%) had undetectable viral load, 30 (13.1%) viral load less than 1000 copies and only 70 (30.6%) had more than 1000 copies, out of these 70 only 57 their viral load persist to be higher thus virologic failure among adult who suspected failing treatment is 24.5% the peak age group where virologic failure is high was 41-60 years (p value <0.1) and 55 patients (98.2%) had virological failure compared to 158 (91.3%) who shows no failure (p value <0.05).
Conclusion: This study had demonstrated poor performance of clinical and immunologic criteria in detecting virologic failure among adults at Bugando medical centre.
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