Evaluation of Bacteriacidal Effect of Medium Chain Fatty Acids Found in Cocos nucifera L. Fixed Oils on Lipid Coated Bacteria Causing Neonatal Sepsis.
Material type:
TextPublisher number: Wurzburg Road 35, BMC Premises, Post Code: 33102: P. O. Box 1464, Mwanza – Tanzania: Phone: +255 28 298 3384: Fax: +255 28 298 3386: Email: vc@bugando.ac.tz www.bugando.ac.tzLanguage: English Language: Kiswahili Publication details: Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS – Bugando] : ©2017Description: vii; 18 Pages; Includes ReferencesSubject(s): Summary: Abstract:
Background: Coco nucifera L. is a common tree known as coconut tree, it contains triglycerides such as caproic, lauric, oleic, capric myristic and palmitic acids which are said to have antimicrobial activity. Neonatal sepsis is a common problem in our setting with common causative agents being gram negative bacteria of Klebsiella pneumoniae and Escherichia coli and gram positive being Staphlococus aureus with an arising in resistance to drugs there is a need for more effective and safer drugs to tackle this problem there for this study was designed to test the antimicrobial activity of the coconut oil on Klebsiella pneumoniae a common causative agent of neonatal sepsis in or setting.
Methodology: Laboratory investigation conducted at CUHAS multipurpose laboratory using a coconut oil extract and archived ESBL producing Klebsilla pneumoniae obtained from infected neonates blood. After a sub culture a disc diffusion test was done using Muller Hinton agar with the sterile virgin coconut oil. A sensitivity comparison disc diffusion test was done with Meropenem and Gentamycin.
Results and Discussion: of 20 bacterial isolates used showed an activity to coconut oil extract with a median of 9mm and an interquartile range of 8-9mm in diameter, 8(40%) had the zone of inhibition of 9mm in diameter and majority 4(20%) isolates had zone diameter of 10mm. all the isolates were sensitive to gentamycin and 55% sensitive to meropenem.
Conclusion and Recommendation: Coconut oil had activity on ESBL producing Klebsiella pneumoniae but less effective compared to gentamycin and meropenem.
| Item type | Current library | Collection | Status | Barcode | |
|---|---|---|---|---|---|
| UNDERGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | 1 | UD0433 |
Abstract:
Background: Coco nucifera L. is a common tree known as coconut tree, it contains triglycerides such as caproic, lauric, oleic, capric myristic and palmitic acids which are said to have antimicrobial activity. Neonatal sepsis is a common problem in our setting with common causative agents being gram negative bacteria of Klebsiella pneumoniae and Escherichia coli and gram positive being Staphlococus aureus with an arising in resistance to drugs there is a need for more effective and safer drugs to tackle this problem there for this study was designed to test the antimicrobial activity of the coconut oil on Klebsiella pneumoniae a common causative agent of neonatal sepsis in or setting.
Methodology: Laboratory investigation conducted at CUHAS multipurpose laboratory using a coconut oil extract and archived ESBL producing Klebsilla pneumoniae obtained from infected neonates blood. After a sub culture a disc diffusion test was done using Muller Hinton agar with the sterile virgin coconut oil. A sensitivity comparison disc diffusion test was done with Meropenem and Gentamycin.
Results and Discussion: of 20 bacterial isolates used showed an activity to coconut oil extract with a median of 9mm and an interquartile range of 8-9mm in diameter, 8(40%) had the zone of inhibition of 9mm in diameter and majority 4(20%) isolates had zone diameter of 10mm. all the isolates were sensitive to gentamycin and 55% sensitive to meropenem.
Conclusion and Recommendation: Coconut oil had activity on ESBL producing Klebsiella pneumoniae but less effective compared to gentamycin and meropenem.
There are no comments on this title.