Adherence to Highly Active Antiretroviral Therapy (HAART) and Clinical Outcome Among People Living With HIV (PLHIV) at Bugando Medical Centre Mwanza
Material type:
TextPublication details: Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS - Bugando] : Phone: +255 28 298 3384 : Fax: +255 28 298 3386 : Email: vc@bugando.ac.tz : Website: www.bugando.ac.tz : ©12.08.2014Description: x; 20 Pages; Includes Refferences and AppendicesSubject(s): Summary: Abstract:
Background: highly active antiretroviral therapy (HAART) is the treatment for people living with HIV (PLHIV) which consists of a combination of at least three drugs that suppress HIV replication. For successful suppression of HIV replication, adherence to the medication is required, which is associated with reduced rates of resistance, an increase in survival rate, improved quality of life and better clinical outcomes such as increase in CD4 count, decrease in viral load and decrease in development of opportunistic infections.
Objective: to determine the relationship between adherences to highly active antiretroviral therapy (HAART) and clinical outcome among people living with HIV (HPLV).
Method: this study was retrospective cross sectional study, which consisted of 146 participants who were 18 year old and above, on first line HAART and who were on HAART for at least one year and above.
Data on adherence were collected by both pill counting and patients self-report through interview guided by questionnaire. Also data on clinical outcome such as CD4 count and development of opportunistic infections were collected from the participant medical records.
Result: 145(99.3%) participants have good adherence and 1(0.7%) participant have poor adherence. The factors which were associated with non-adherence were being away from home, forgetfulness, sleeping, having problems in swallowing tablets at specific times, sickness and running out of tablets.
Also among 133 who didn’t miss doses, 128/133 (96.2%) didn’t develop opportunistic infection and 5/133 (3.8%) developed opportunistic infection and among 13 participants who missed doses none of them developed opportunistic infection (p- value =0.477). and among 13 participants who missed doses,2/13 (15.4%) had decreased in recent CD4 count and among 133 patients who didn’t miss the doses, 8/133 (6.0%) had decreased in recent CD4 count (p- value=0.609).
Conclusion: the one month adherence rate at Bugando Medical Centre is 99.3%, and there is no association between adherence and clinical outcome such as increase in CD4 count and opportunistic infection.
| Item type | Current library | Collection | Status | Barcode | |
|---|---|---|---|---|---|
| UNDERGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | 2 | UD0044 |
Abstract:
Background: highly active antiretroviral therapy (HAART) is the treatment for people living with HIV (PLHIV) which consists of a combination of at least three drugs that suppress HIV replication. For successful suppression of HIV replication, adherence to the medication is required, which is associated with reduced rates of resistance, an increase in survival rate, improved quality of life and better clinical outcomes such as increase in CD4 count, decrease in viral load and decrease in development of opportunistic infections.
Objective: to determine the relationship between adherences to highly active antiretroviral therapy (HAART) and clinical outcome among people living with HIV (HPLV).
Method: this study was retrospective cross sectional study, which consisted of 146 participants who were 18 year old and above, on first line HAART and who were on HAART for at least one year and above.
Data on adherence were collected by both pill counting and patients self-report through interview guided by questionnaire. Also data on clinical outcome such as CD4 count and development of opportunistic infections were collected from the participant medical records.
Result: 145(99.3%) participants have good adherence and 1(0.7%) participant have poor adherence. The factors which were associated with non-adherence were being away from home, forgetfulness, sleeping, having problems in swallowing tablets at specific times, sickness and running out of tablets.
Also among 133 who didn’t miss doses, 128/133 (96.2%) didn’t develop opportunistic infection and 5/133 (3.8%) developed opportunistic infection and among 13 participants who missed doses none of them developed opportunistic infection (p- value =0.477). and among 13 participants who missed doses,2/13 (15.4%) had decreased in recent CD4 count and among 133 patients who didn’t miss the doses, 8/133 (6.0%) had decreased in recent CD4 count (p- value=0.609).
Conclusion: the one month adherence rate at Bugando Medical Centre is 99.3%, and there is no association between adherence and clinical outcome such as increase in CD4 count and opportunistic infection.
There are no comments on this title.