Includes bibliographical references and index.

Overview of drug development / James A. Popp and Jeffery A. Engelhardt -- Nonclinical safety evaluation of drugs / Thomas M. Monticello and Jeanine L. Bussiere -- Nonclinical safety evaluation of advanced therapies / Timothy MacLachlan, Kendall S. Frazier, and Mercedes Serabian -- Nonclinical safety evaluation of medical devices / Kathleen A. Funk, Victoria A. Hampshire, and JoAnn C.L. Schuh -- Pathology and the pathologist in pharmaceutical research and development / Page R. Bouchard, Christopher J. Clarke, and Dominique Brees -- Routine and special techniques in toxicologic pathology / Daniel J. Patrick, Matthew L. Renninger, and Peter C. Mann -- Principles of clinical pathology / Niraj K. Tripathi and Jacqueline M. Tarrant -- Toxicokinetics and drug disposition / David D. Christ -- Toxicogenomics in toxicologic pathology / Arun R. Pandiri, David E. Malarkey, and Mark J. Hoenerhoff -- Spontaneous lesions in control animals used in toxicity studies / Robert C. Johnson, Robert H. Spaet, Gitte Jeppersen, Ursula Junker, and Robert Stull -- Gastrointestinal tract / Judit E. Markovits, Graham R. Betton, Donald N. McMartin, and Theresa Boulineau -- Liver, gallbladder, and exocrine pancreas / Russell C. Cattley, James A. Popp, and Steven L. Vonderfecht -- Respiratory system / Tom P. McKevitt and David J. Lewis -- Urinary System / Kendall S. Frazier and John Curtis Seely -- Hematopoietic system / Kristin Henson, Tanasa Osborne, and Gregory S. Travlos -- Lymphoid system / Patrick J. Haley -- Bone, muscle, and tooth / John L. Vahle, Joel R. Leininger, D. Greg Hall, and Heinrich Ernst -- Cardiovascular system / Calvert Louden and David Brott -- Endocrine glands / Richard A. Peterson, Sundeep Chandra, and Mark J. Hoenerhoff -- Reproductive system and mammary gland / Justin D. Vidal, Charles E. Wood, Karyn Colman, Katharine M. Whitney, and Dianne M. Creasy -- Skin / Zbigniew W. Wojcinski, Lydia Andrews-Jones, Daher Ibrahim Aibo, Rie Kikkawa, and Robert Dunstan -- Nervous system / Mark T. Butt, Alys Bradley, and Robert Sills -- Special senses / Kenneth A. Schafer, Richard A. Altschuler, and Oliver C. Turner.