Contents:

1 The Prevalence and Impact of Neurological Disease in Cancer

Diagnostic Studies

2 Imaging Neurologic Manifestations of Oncologic Disease

EEG EMG and Lumbar Puncture

Nervous System Involvement of Systemic Cancers

4 Brain Metastasis as Complication of Systemic Cancers

5 Leptomeningeal Metastasis as Complication of Systemic Cancers

6 Spinal Metastasis as Complication of Systemic Cancers

18 Neurologic Complications of Hematopoietic Stem Cell Transplantation

19 Neurologic Complications of Corticosteroids in Cancer Therapy

20 Central Nervous System Infections in Patients Receiving Cancer Therapies

Neurological Complications of Specific Malignancies

21 Neurological Complications of Primary Brain Tumors

22 Neurological Complications of Lung Cancer

23 Neurological Complications of Breast Cancer and Its Treatment

24 Neurologic Complications of Gastrointestinal Cancer


7 Peripheral Nervous System Metastases as Complications of Systemic Cancer

Neurological Complications of Cancer

8 Headache as Complication of Cancer

9 Seizures as Complications in Cancer

10 Cerebrovascular Complications of Cancer

11 Elevated Intracranial Pressure and Hydrocephalus in Brain Tumor Patients

12 Cognitive Dysfunction Mood Disorders and Fatigue as Complications of Cancer

13 Paraneoplastic Syndromes of the Nervous System as Complications of Cancer

Neurological Complications of Cancer Therapy

14 Neurologic Complications of Radiation Therapy

15 Neurological Complications of Chemotherapy

16 Neurological Complications of Targeted Therapies

17 Neurological Complications of ImmuneBased Therapies

25 Neurologic Complications of Genitourinary Cancer

26 Neurologic Complications of Female Reproductive Tract Cancers

27 Neurological Complications of Sarcomas

28 Neurologic Complications of Head and Neck Cancer

29 Neurological Complications of Malignant Melanoma

30 Neurological Complications of Leukemia

31 Neurologic Complications of Lymphoma

32 Neurologic Complications of Plasma Cell Dyscrasias

33 Neurologic Complications of Pediatric Systemic Cancer

Neurological Complications in Long Term Cancer Survivors

34 Neurological Complications of Cancer and Cancer Therapies in LongTerm Survivors
Index

This updated edition provides clinicians from various backgrounds and levels of training the information needed to optimally diagnose and manage neurologic complications of the nervous system. Organized into seven sections, this comprehensive volume begins with an overview of diagnostic studies for neurologic complications involving the nervous system. That is followed by sections on metastatic and non-metastatic complications of cancer involving the nervous system, and the interpretation, diagnosis, and management of common neuro-oncologic symptoms. The next section reviews the neurologic complications of cancer therapy, including corticosteroids, radiation therapy, chemotherapy, targeted molecular therapies, immunotherapies, hematopoietic stem cell transplantation, and infections involving the nervous system. The final section focuses on the most important neurologic complications in cancers arising from specific organs. In addition to capturing the latest advancements in the rapidly evolving fields of oncology and cancer neurology, the goal of this resource is to lead clinicians toward prompt diagnosis and intervention in order to improve patient quality of life.
"This textbook is a valuable resource for medical oncologists and radiation oncologists, as well as neurologists and neuro-oncologists dealing with these patients. ... Overall, the chapters are well organized, clearly written, fairly balanced, and reasonably up to date. ... I would recommend it as a learning tool to physicians in training (medical students, residents, and fellows) and for more experienced physicians as both a review/ update and a way to gain more in-depth knowledge and insight into the neurologic problems of cancer patients." (John C. Flickinger, International Journal of Radiation Oncology Biology Physics, Vol. 73 (2), 2009)

"The general organization of the book is logical and facilitates its practical and everyday use. ... Overall this textbook is very comprehensive and encompasses main neuro-oncological challenges. ... Schiff, Kesari and Wen have edited a very elegant and highly practical textbook, written by recognized authorities in their respective fields, which will be used by a wide range of medical and surgical specialists who are confronted on a daily basis with neurological manifestations of cancer in their practice." (I. Radovanovic and G. Zadeh, British Journal of Cancer, Vol. 100 (6), 2009) Common terms and phrases: acute agents antibodies associated bevacizumab brain metastases brain tumors breast cancer cancer patients cell carcinoma cell lung cancer central nervous system cerebellar cerebral chemotherapy chronic cisplatin Clin Oncol clinical cognitive corticosteroids cranial deficits demyelinating dexamethasone diagnosis disease disorders dose drug dysfunction edema effects encephalitis encephalopathy factors gliomas headache hemorrhage high-dose imaging incidence increased infection inhibitors Int J Radiat intra-CSF intracranial intrathecal ipilimumab irradiation leptomeningeal metastases lesions leukemia leukoencephalopathy limbic encephalitis lung cancer lymphoma malignant median melanoma meningioma meningitis methotrexate months muscle neoplastic nerve Neurol neurologic complications Neurooncol Neurosurg neurotoxicity Oncol Biol Phys paclitaxel paraneoplastic patients treated patients with brain peripheral neuropathy phase plexopathy plexus posterior primary prognostic protein Radiat Oncol Biol radiation therapy radiation-induced radiotherapy receptor reported risk sarcoma seizures sensory solid tumors spinal cord stereotactic radiosurgery steroids surgery survival symptoms syndrome temozolomide toxicity transplantation trastuzumab treatment trial WBRT