TY - BOOK AU - Ozcan Basaran AU - Murat Biteker TI - Anticoagulation Therapy SN - 9789535126669 U1 - 615 PY - 2016/// CY - New York PB - BoD – Books on Demand, KW - N1 - Contents: Comparative Biology of the Resistance to Vitamin The Risk Factors of Thrombogenic Thrombophilia and Management of Anticoagulation Around Cardiac Implantable Prothrombin Complex Concentrate a General Antidote for Oral NonVitamin K Antagonist Oral Anticoagulants in Atrial NonVitamin K Antagonist Oral Anticoagulants Clinical Use N2 - The available parenteral and oral anticoagulants have a large clinical use. Understanding biochemistry of anticoagulants may help to improve therapeutic strategies. Resistance to vitamin K antagonist drugs might be a problem for rodent populations. Patients who have thrombogenic risk factors should be anticoagulated. The need for cardiac implantable electronic devices is increasing, and there is a substantial number of patients who are on oral anticoagulant therapy. Prothrombin complex concentrate and other plasma concentrates are useful to deal with over-coagulated situations. The efficacy and safety of non-vitamin K antagonist oral anticoagulants have been proven in large phase III trials. The real-world data suggest even better outcomes with these agents compared to vitamin K antagonists ER -