Genetic Damage in Human Spermatozoa
- 2nd edition
- Department of Clinical and Experimental Medicine University of Florence Florence, Italy: Springer, c2019
- 210 pages
- Volume 1166 of Advances in Experimental Medicine and Biology .
There are several types of damage that can be found in the male gamete. This book covers the genetic damage in spermatozoa that can originate during spermatogenesis, or during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.
9783030216641 3030216640
= Common terms and phrases abnormal Agarwal Aitken RJ alterations Andrology aneuploidy antioxidant apoptosis apoptotic assisted reproduction associated Biol Reprod Carrell DT chemotherapy chromatin structure assay chromosome clinical Comet assay correlation cryopreservation deletion DNA breaks DNA frag DNA methylation effect ejaculated epigenetic epigenome Esteves SC evaluated exposure factors Fertil Steril function genome germ cells germline histone https://doi Hum Reprod human sperm human spermatozoa ICSI impact increased induced intracytoplasmic sperm injection levels male infertility matozoa membrane mentation meta-analysis mice mouse Muratori mutations novo nuclear offspring oocyte outcome oxidative damage oxidative stress parameters paternal age patients potential protamine protein reduced Reprod Biomed Online risk RNAs SCSA semen samples sper sperm cells sperm chromatin structure sperm DNA damage sperm DNA fragmentation sperm DNA integrity sperm DNA methylation sperm epigenome sperm selection spermatids spermato spermatogenesis spermatozoa studies testicular testis tion transgenerational treatment TUNEL Urol varicocele vitro fertilization Zhang
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