Biliary Disease From Science to Clinic
- Centre for Liver Research NIHR Biomedical Research Unit Institute of Immunology and Immunotherapy University of Birmingham Birmingham United Kingdom Publisher Springer c2017
- 264 pages
Contents:
The Clinical Burden of Biliary Disease A Global Perspective
The Healthy Biliary Tree Cellular and Immune Biology
Pathological Features of Biliary Disease in Children and Adults
Animal Models of Biliary Disease Current Approaches and Limitations
The Microbiome and Human Disease A New Organ of Interest in Biliary Disease
Biliary Atresia From Pathology to Treatment
DrugInduced Cholestasis Mechanisms and Importance
Primary Biliary Cholangitis Its Science and Practice
Primary Sclerosing Cholangitis PSC Current Concepts in Biology and Strategies for New Therapy
Cholangiocarcinoma Disease Pathogenesis and New Treatment Paradigms
Gallstone Disease Scientific Understanding and Future Treatment
IgG4Related Sclerosing Cholangitis
Conclusions and Future Opportunities
This book addresses the current understanding of the diagnosis and management of biliary disease across all ages, with emphasis on how the latest advances in clinical science may be integrated into current and future therapies. The coverage is wide ranging, encompassing congenital and acquired conditions including cholestatic syndromes, biliary atresia, drug-induced cholestasis, primary biliary cholangitis/cirrhosis, primary sclerosing cholangitis, cholangiocarcinoma, gallstone disease, and autoimmune sclerosing cholangitis. With contributions from basic and clinical scientists, the relevance of state-of-the-art mechanistic biology to diagnosis, treatment, and future opportunities for drug design is clearly explained. The balance between science and clinical practice will ensure that this book makes a lasting contribution to the field. A broad readership will find the book easy to access and a rich source of information on current best practice and evolving management strategies.
3319501682 9783319501680
= ABCB4 activation animal models antibodies antigen associated autoantibodies autoimmune hepatitis Beuers bile acid bile duct biliary atresia biliary disease biliary tree bilirubin biochemical cancer carcinoma cholangiocarcinoma cholangiocytes cholangiopathies cholestasis cholestatic cholesterol chronic Clin clinical trials colitis cytokines diagnosis DILI drug ductular expression extrahepatic gallbladder gallstone Gastroenterol Hepatol Gastroenterology gene genetic Gershwin gut microbiome HCO3 hepatobiliary hepatocellular hepatocytes Hepatology Hirschfield histological human IgG4-SC immune Immunol incidence increased induced inflammation inflammatory intestinal intrahepatic intrahepatic bile ducts Kasai Lindor KD liver biopsy liver disease liver fibrosis liver injury liver transplantation lymphocytes malignancy metabolism mice microbiome microbiota mouse model mutations outcome pancreatitis pathogenesis pathways patients with PBC patients with primary PBC patients Pediatr phenotype portal Poupon prevalence primary biliary cirrhosis primary sclerosing cholangitis protein receptor response risk factors role syndrome T-cells targeting therapeutic therapy tion treatment Tsuneyama UDCA ursodeoxycholic acid Wang Zhang
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