Robert E. Kass <br/><br/>
Basis and Treatment of Cardiac Arrhythmias  

 - 	illustrated  
 - Department of Pharmacology 630 W. 168 St. New York, NY 10032;  Springer Science & Business Media  c2006 
 - 	361 pages 	 
 -  Volume 171 of Handbook of Experimental Pharmacology  .
<br/><br/>Contents:<br/><br/>HistoryofArrhythmias<br/><br/>Mechanisms of Arrhythmias<br/><br/>Conclusions<br/><br/>Proarrhythmia<br/><br/>Cardiac Na+ Channels as Therapeutic Targets<br/><br/>Structural Determinants of Potassium Channel Blockade<br/><br/>A Role for CalciumCalmodulinDependent Protein Kinase II<br/><br/>AKAPsasAntiarrhythmicTargets?<br/><br/>βBlockersasAntiarrhythmicAgents<br/><br/>MutationSpecific Pharmacology of the Long QT Syndrome<br/><br/>TherapyfortheBrugadaSyndrome<br/><br/>Molecular Basis of Isolated Cardiac Conduction Disease<br/><br/>hERG Trafficking and Pharmacological Rescue<br/> 
<br/><br/> This book incorporates the most up-to date information related to mechanisms and treatment of cardiac arrhythmia. Many of the topics discussed in this text reflect very recently undertaken research directions including genetics of arrhythmias, cell signalling molecules as potential therapeutic targets and trafficking to the membrane. These new approaches and implementations of anti-arrhythmic therapy derive from many decades of research as outlined in the first chapter by distinguished Professors Michael Rosen (Columbia University) and Michiel Janse (University of Amsterdam). The text covers changes in approaches to therapy over time, arrhythmias in multiple cardiac regions and over many scales, from gene to protein to cell to tissue to organ. 
<br/><br/><label>ISBN: </label>3540297154 9783540297154  
 = Acad Sci U S A action potential activity adrenergic afterdepolarizations Antzelevitch arrhythmogenic atrial fibrillation Biol Chem block Brugada syndrome Ca2+ overload calcium CaMKII canine cardiac arrhythmias Cardiol Cardiovasc Res cells cellular channel blockers Circ Res Circulation clinical delayed rectifier DiFrancesco disease domain drug-induced effects electrocardiogram electrophysiological flecainide function gene genetic heart failure HERG hypertrophy inactivation increased infarction inhibition intracellular ion channel isoforms K+ current Kass KCNE1 KCNH2 KCNQ1 Keating MT long QT syndrome LQT3 LQTS mechanism membrane modulation molecular mutations myocardial Na/Ca exchanger Na+ channel Natl Acad Sci Nattel node outward current pacemaker patients Pharmacol pharmacological phosphorylation Physiol Lond polymorphic potassium channel Priori SG proarrhythmia Proc Natl Acad prolongation protein kinase Purkinje fibers quinidine rabbit receptor regulation repolarization Roden DM role ryanodine SA node Sanguinetti MC Schwartz PJ SCN5A sodium channel Splawski studies subunits therapy torsades de pointes ventricular myocytes voltage Wang 
<br/><br/><label>Subjects--Personal Names: </label>--Arrhythmia.--Medical › Pharmacology--  Medical / Cardiology --Medical / Pharmacology-- Medical / Pharmacy --Medical / Physiology
<br/><br/><label>Dewey Class. No.: </label>616.1/28 KAS