TY - BOOK AU - Edward D. Levin AU - Jerry J. Buccafusco TI - Animal Models of Cognitive Impairment : Frontiers in Neuroscience SN - 1420004336 U1 - 616.8 LEV PY - 2006/// CY - London PB - CRC Press KW - N1 - Contents: 1 Introduction 2 Muscarinic Receptor Antagonists in Rats 3 Nicotinic Receptor Antagonists in Rats 4 Involvement of the NMDA System in Learning and Memory 5 Animal Models and the Cognitive Effects of Ethanol 6 Animal Models of Cognitive Impairment Produced by Developmental Lead Exposure Consequences Conditioning and Cortex What Animal Models Have Told Us 9 Modeling Cognitive Deficits Associated with Parkinsonism in the ChronicLowDose MPTPTreated Monkey 10 Cognitive Impairment in Transgenic Mouse Models of Amyloid Deposition 11 Cholinergic Receptor Knockout Mice 12 Assessments of Cognitive Deficits in Mutant Mice 13 Cognitive Pharmacology in Aging Macaques 14 Cognitive Impairment following Traumatic Brain Injury 15 Cognitive Impairment Models Using Complementary Species 16 Cognition Models and Drug Discovery Index N2 - The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen ER -