Esen Özkaya

Adverse Cutaneous Drug Reactions to Cardiovascular Drugs - illustrated - Department of Dermatology Istanbul University Istanbul Medical Faculty Istanbul Turkey Springer 2014 - 259 pages

Adverse cutaneous drug reactions (ACDR) are among the most frequent events in patients receiving drug therapy. Cardiovascular (CV) drugs are an important group of drugs with potential risk of developing ACDR especially in elderly as marketing of more new drugs and their prescription continue to increase. However, like with most other drugs the exact incidence of cutaneous side effects from CV drugs is difficult to estimate due to sporadic reporting. Moreover, a reliable designation of a certain drug as the cause of a certain type of reaction can rarely be made. Apart from the well-known angioedema/urticaria from ACE inhibitors, lichen planus / lichenoid reaction from beta adrenergic blockers and photosensitivity from thiazid diuretics, ACDR from CV drugs might be seen in a wide spectrum extending to rare but life-threatening conditions such as erythroderma, Stevens-Johnson syndrome, toxic epidermal necrolysis or drug hypersensitivity syndrome. In this comprehensive review, the reported types of ACDR to CV drugs will be discussed according to drug class and the type of dermatologic reaction with special emphasize on cross-reactions and the role of patch testing in diagnosis.

1447165365 9781447165361 = Acad Dermatol ACEIs acetazolamide Acute generalized exanthematous adverse cutaneous drug AGEP Allergy alopecia amiodarone amlodipine angioedema Angioedema/urticaria angiotensin II receptor antibodies ARBs Arch Dermatol aspirin associated beta-blockers bullous pemphigoid captopril cardiovascular drugs cause CCBs Clin Exp Dermatol clinical clopidogrel Contact Dermatitis corticosteroids cross-reactivity cutaneous adverse cutaneous drug reactions cutaneous reactions Dermatol Venereol diltiazem diuretics drug rash Drug-induced lupus erythematosus eczematous eruption edema enalapril eosinophilia and systemic erythema multiforme erythroderma exanthematous pustulosis Fixed drug eruption furosemide heparin hydrochlorothiazide hyperpigmentation hypersensitivity reactions induced lesions lichen planus Lichenoid drug eruption lichenoid eruption lisinopril LMWHs losartan maculopapular eruption methyldopa mexiletine mucosal necrosis nifedipine oral Özkaya patch test patch test reactions patients pemphigus phenytoin photopatch testing photosensitivity positive patch test propranolol Pruritus psoriasis purpura quinidine rash with eosinophilia receptor blockers rechallenge reported simvastatin statins Stevens-Johnson syndrome Stevens–Johnson subacute cutaneous lupus sulfonamide systemic symptoms therapy ticlopidine toxic epidermal necrolysis ulcers urticaria valsartan vasculitis verapamil

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