TY - BOOK AU - Kenakin,Terrence P. TI - A pharmacology primer: techniques for more effective and strategic drug discovery SN - 9780124076631 AV - RM301.25 .K46 2014 U1 - 615/.7 KEN 23 PY - 2014/// CY - Amsterdam, Boston PB - Academic Press KW - Pharmacology, Experimental KW - Pharmacology N1 - Includes bibliographical references and index; What is pharmacology? -- How different tissues process drug response -- Drug-receptor theory -- Pharmacological assay formats : binding -- Agonists : the measurement of affinity and efficacy in functional assays -- Orthosteric drug antagonism -- Allosteric modulation -- The optimal design of pharmacological experiments -- Pharmacokinetics -- Safety pharmacology -- The drug discovery process -- Statistics and experimental design -- Selected pharmacological methods -- Exercises in pharmacodynamics and pharmacokinetics UR - http://www.loc.gov/catdir/enhancements/fy1606/2013372396-d.html ER -