TY  - BOOK
AU  - 	Curtis D. Klaassen 
TI  - Casarett & Doull's Toxicology: The Basic Science of Poisons
SN  - 	0071593519
U1  - 615.9 
PY  - 2007///
CY  - London 
PB  - McGraw Hill Professional
KW  -  
N1  - Contents:

Unit 2 Disposition of Toxicants   129

Unit 3 NonOrganDirected Toxicity   327

Unit 4 Target Organ Toxicity   453

N2  - The most complete, trusted reference-text covering the full span of medical toxicology
Market: Students, toxicologists, and pharmacologists
Focuses on the principles, concepts, and modes of thought that are the foundation of the discipline
New to this edition: updated throughout to reflect new understanding of cell death and drug metabolism, new content on chemical terrorism, many new contributors; Common terms and phrases:


absorption acid activity addition agents alterations animals appears aromatic assays associated binding blood cancer carcinogens catalyzed cause cells cellular changes chemical chromosome compartment compounds concentration conjugation contain cytochrome P450 damage decrease detected determined developmental differences dose drugs effects elimination enzymes et al evaluation example excretion exposure expression factors Figure formation function gene genetic glucuronide glutathione growth half-life Health human important increased individuals induced inhibition inhibitors initial interactions involved known lead levels liver lung major mechanisms membrane metabolism metabolites mice molecules mouse mutagenic mutations normal observed occur organ oxidase oxidative oxygen pathway Pharmacol placenta plasma potential produce proteins rats reactions reactive receptor reduction relatively repair response risk risk assessment role shown signaling species structure studies substrates Table tion tissue toxicity Toxicol toxicology transport tumor vitro whereas xenobiotics
ER  -