Drug product development for the back of the eye /
Uday B. Kompella, Henry F. Edelhauser, editors.
- New York : [Arlington] : Springer ; AAPS Press, c2011.
- xii, 590 p. : ill. (some col.) ; 24 cm.
- AAPS advances in the pharmaceutical sciences series, 2 2210-7371 ; .
- AAPS advances in the pharmaceutical sciences series ; v. 2. .
Includes bibliographical references and index.
Selection of drug delivery approaches for the back of the eye: opportunities and unmet needs / Microdialysis for vitreal pharmacokinetics / Fluorophotometry for pharmacokinetic assessment / Systemic route for retinal drug delivery: role of the blood-retinal barrier / Topical drug delivery to the back of the eye / Principles of retinal drug delivery from within the vitreous / Transscleral drug delivery / Suprachoroidal and intrascleral drug delivery / Advances in biodegradable ocular drug delivery systems / Microparticles as drug delivery systems for the back of the eye / Nanotechnology and nanoparticles / Hydrogels for ocular posterior segment drug delivery / Refillable devices for therapy of ophthalmic diseases / Targeted drug delivery to the eye enabled by microneedles / Ocular iontophoresis / Drug and gene therapy mediated by physical methods / Protein drug delivery and formulation development / Drug suspension development for the back of the eye / Regulatory considerations in product development for the back of the eye / Clinical endpoints for back of the eye diseases / Druggable targets and therapeutic agents for disorders of the back of the eye / Development of bile acids as anti-apoptotic and neuroprotective agents in treatment of ocular disease / David A. Marsh -- Ravi D. Vaishya, Hari Krishna Ananthula, and Ashim K. Mitra -- Bernard E. McCarey -- Masanori Tachikawa, Vadivel Ganapathy, and Ken-ichi Hosoya -- Thomas Gadek and Dennis Lee -- Clive G. Wilson, Lay Ean Tan, and Jenifer Mains -- Dayle H. Geroski and Henry F. Edelhauser -- Timothy W. Olsen and Brian C. Gilger -- Susan S. Lee, Patrick Hughes, Aron D. Ross, and Michael R. Robinson -- Rocio Herrero-Vanrell -- Shelley A. Durazo and Uday B. Kompella -- Gauri P. Misra, Thomas W. Gardner, and Tao L. Lowe -- Alan L. Weiner -- Samirkumar R. Patel, Henry F. Edelhauser, and Mark R. Prausnitz -- Francine F. Behar-Cohen, Peter Milne, Jean-Marie Parel, and Indu Persaud -- John M. Nickerson and Jeffrey H. Boatright -- Rinku Baid, Puneet Tyagi, Shelley A. Durazo, and Uday B. Kompella -- Jithan Aukunuru, Puneet Tyagi, Chandrasekar Durairaj, and Uday B. Kompella -- Ashutosh A. Kulkarni -- Karl G. Csaky -- Robert I. Scheinman, Sunil K. Vooturi, and Uday B. Kompella -- Stephanie L. Foster, Cristina Kendall, Allia K. Lindsay, Alison C. Ziesel, Rachael S. Allen, Sheree S. Mosley, Esther S. Kim, Ross J. Molinaro, Henry F. Edelhauser, Machelle T. Pardue, John M. Nickerson, and Jeffrey H. Boatright.