Prevalence and Associated Factors of Cardiac Autonomic Neuropathy among Diabetic Patients at Bugando Medical Centre, Mwanza, Tanzania.
- Mwanza, Tanzania | Catholic University of Health and Allied Sciences [CUHAS-Bugando] | 2023.
- Pages xii- 113 Includes References
Abstract:
Introduction: DM has been implicated with multiple complication including diabetic cardiac autonomic neuropathy (DCAN), with a global burden ranging from 1-90% in type 1 DM and 20-73% in type 2 DM. Poor glycaemic control, long duration of DM and traditional cardiovascular risk factors have been associated with the development and progression of DCAN. In Tanzania, there is limited data on DCAN burden and its associated factors. This study was conducted to fill the knowledge gap and raise awareness about DCAN.
Objectives: To determine prevalence and associated factors of cardiac autonomic neuropathy among diabetic patients at Bugando Medical Centre, Mwanza, Tanzania.
Methodology: A hospital-based cross-sectional study conducted in DM MOPD at BMC, with a sample size of 383 DM patients. A standard questionnaire was used for data collection, and DCAN diagnosis was made using cardiovascular autonomic reflex tests (CARTS). Data was analyzed using STATA version 15, DCAN associated factors were analysed using bivariate logistic regression models.
Results: Our of 383 patients, 49.1% (188) had DCAN with heart rate variability being the most common abnormality 38.9% (149) and postural hypotension being the least 2.4% (9) among DCAN patients. Obesity, presence of pathological Q and resting tachycardia were significantly associated with DCAN. Though statistically significant, Age peripheral neuropathy, HbAIC, dyslipidemia, hypertension and DM duration were not analysed in the final model because of collinearity with BMI, pathological Q and resting tachycardia.
Conclusion: DCAN is prevalent in about half of the DM patients attending medical outpatient clinic at BMC. Obesity and pathological Q were are identified factors associated with DCAN; measures should be taken to address the increase in obesity in our population as well as a rest ECG should be performed in diabetic patients more so DCAN patients to address the grave clinical repercussion associated with pathological Q wave.
Wurzburg Road 35, Premises, Post Code: 33102 | P. O. Box 1464 Mwanza, Tanzania | Phone: (255) 28-298-3384 | Fax: (255) 28-298-3386 | Email: vc@bugando.ac.tz | Website: www.bugando.ac.tz