TY  - BOOK
AU  -   Shemmela, Hamidu
AU  - Masalu, Nestory
TI  -      Adverse Drug Reactions Profile Among Patients Received Taxane-Based Chemotherapy for Different Cancer Types at Bugando Medical Centre, Mwanza, Tanzania
PY  - 2019///
CY  - Mwanza, Tanzania: 
PB  - Catholic University of Health and Allied Sciences [CUHAS – Bugando] :   
KW  -  
N2  - Abstract:

Background: Taxanes are class of ant microtubule anticancer agents which originally identified from plants of genus Taxus and they are amongst the most promising antitumor agents available at hand today and they are of increasing importance in worldwide given that cancer is now of the major public health problems which needs to death urgently for the benefit of affected patients. Taxanes and taxane-based chemotherapies are associated with ADRs such as peripheral neuropathy, myelosuppression, arthralgia, myalgia and skin reactions that may adversely affect patient-reported quality of life. This toxicity is cumulative across course of therapy, can be a dose-limiting and may lead to dose reaction or cessation of therapy.   

Methodology: This was retrospective cross-sectional hospital based study conducted from January 2014 to December 2018. The study involved both inpatients and outpatients who had any cancer type in which taxanes alone or with other chemotherapies were prescribed, and attended at oncology department from January 2014 to December 2018. All retrieved files were observed and obtained data were filled in the data collection tool. 

Results: Total of 136 files were retrieved, and found to contain taxane-based chemotherapies and analyzed using SPSS version 20, out of these files, only 117 files were documented  for adverse drug reactions, and 104 patients developed ADRs while 13 patients had no complain, while in 19 files the ADRs were documented, and the prevalence of developing ADRs was 88.89%, in which nausea and vomiting, alopecia and peripheral neuropathy were commonly developed by large number of patients compared to other ADRs. 

Discussion: This higher prevalence of ADRs could be because of lack of delivering periodic ADR awareness sessions to treating physicians and nurses, lack of active involvement of clinical pharmacies and pharmacists in clinical activities in Bugando medical centre. The documented ADRs are mainly affecting the gastrointestinal tract, bone marrow and skin and this study also pointed out the same. 

Conclusion: This study provided basic information regarding the ADRs profile of taxanes bases chemotherapy in variety of cancer types. Nevertheless, early detection of these ADRs may help in minimizing the damage by either modifying the dose or changing the medications.

ER  -