TY  - BOOK
AU  -  Lupagalo, Gabriel
AU  - Mushi, Martha
AU  - Mshana, Stephen. E
TI  -   Prevalence and Susceptibility Patterns of Enteric Pathogens Causing Non-Significant Bacteriuria Among Symptomatic Patients Attending Hospitals in Mwanza City Tanzania
PY  - 2019///
CY  - Mwanza, Tanzania: 
PB  - Catholic University of Health and Allied Sciences [CUHAS – Bugando] :   
KW  -  
KW  - Microbiology & Immunology
N2  - Abstract: 

Background: Non-significant bacteriuria is a condition where by the urine sample of a symptomatic patient contains less than ten power four colony forming unit per milliliter of voided urine (<104 CFU/l). Most common enteric bacteria causing urinary tract infection includes Escherichia coli, Klebsiella spp, Proteus spp, Citrobacter spp, Enterobacter spp, etc. The majority of pathogens causing non-significant bacteriuria are resistant to common antibiotics such as amplicillin, trimethoprim sulphamethaxazole, tetracycline, ciprofloxacillin, gentamycin, ceftazidime, ceftriaxone etc. Complication of non-significant bacteriuria include elevated risk of pyelonephritis, premature labour, fetal death, pregnancy induced hypertension, transient renal failure, sepsis and shock during pregnancy. The impacts of UTI include increasing morbidity and mortality rate among patients, increasing treatment costs and increasing risk of multi drug resistance (MDR) development. 

Objectives: The study has determined the prevalence and susceptibility pattern of pathogens causing non-Significant bacteriuria among patients with symptoms of UTI at Mwanza City-Tanzania. 

Methodology: The study was hospital based, cross sectional study involving 357 cultured plates with Non-Significant bacteriuria. All patient’s samples with less 104 CFU was selected and processed for purity plate (PP), ID test and antimicrobial susceptibility test. All data was recorded into laboratory log book then entered into excel for cleaning ad coding. Analysis was done by using STATA as per study objective. 

Results: A total of 1888 patients were recruited in this study from which 357 (18.9%) patients had non-significant bacteria growth. Out of 357 non-significant bacteria growth, 113 (31.65%) were enteric gram negative bacteria. The prevalent enteric gram negative bacteria isolated were Escherichia coli 50 (44.3%) followed by Non fermentative gram negative bacteria 24 (21.2%), Pseudomonas aeruginosa 10 (8.8%), Acinetobacter spp. 7 (6.2%), Enterobacter cloacae 7 (6.2%) and other bacteria 15 (13.3%). Out of 113 enteric gram-negative bacteria, 33 (29.2%) were multi-drug resistance (MDR). E. coli was predominant MDR 9(27.3%). 

Conclusion: Nonsignificant bacteriuria in Mwanza is predominantly caused by enteric gram negative bacteria lead by E. coli. About one third of E. coli causing non-significant bacteriuria are MDR.   More studies on the outcome of non-significant bacteriuria are recommended. 


ER  -