TY  - BOOK
AU  - Vicky P Manyanga
AU  -  Emmanuel Kimaro
AU  - Joseph Sempombe
AU  - Eliangiringa Kaale
AU  - Mhina Chambuso
TI  - A High-performance Thin Layer Chromatography Densitometric Method for the assay of Mebendazole Tablets
SN  - eISSN: 10
PY  - 2020///-10-01
CY  - Mwanza
PB  -  Tanzania  Catholic University of Health and Allied Sciences [CUHAS – Bugando]  &,  East and Central African Journal of Pharmaceutical Sciences
N2  - Abstract

A simple, precise and accurate high-performance thin layer chromatographic (HPTLC) method was developed for the assay of mebendazole tablets. The separation was carried out by using HPTLC Silica gel 60 F254, (20 × 10 cm) with 250 μm thickness using ethyl acetate - ammonia 25% solution (25:0.5) as a mobile phase. HPTLC separation of the drug was followed by densitometry measurement at 310 nm. Mebendazole was satisfactorily resolved with retention factor (Rf) values of 0.51 ± 0.02. The method complied with International Conference on Harmonization acceptance
criteria for linearity (250 - 600 ng), precision, accuracy and specificity
ER  -