TY  - BOOK
AU  - M.Seugendo
AU  - S.E.Mshana
AU  - A.Hokororo
AU  - B.Okamo
AU  - M.M.Mirambo
AU  - L.von Müller
AU  - K.Gunka
AU  - O.Zimmermann
AU  - U.Groß
TI  - Clostridium difficile infections among adults and children in Mwanza/Tanzania: is it an underappreciated pathogen among immunocompromised patients in sub-Saharan Africa?
T2  - New Microbes and New Infections Volume 8, November 2015
PY  - 2015///
CY  - Mwanza, Tanzania 
PB  -  Catholic University of Health and Allied Sciences CUHAS - Bugando
N2  - Abstract

Little is known regarding the epidemiology Clostridium difficile in developing countries. Fresh stool samples from patients with diarrhoea were cultured anaerobically. C. difficile was detected in nine (6.4%) of 141 (95% confidence interval 4.2–13.1), of which seven (77.8%) were from children. HIV infection, prolonged hospitalization and antibiotic use were independent factors associated with the occurrence of C. difficile in the gastrointestinal tract. Two of the toxigenic isolates were typed as ribotype 045, and the other two had unknown ribotype. All C. difficile isolates were susceptible to metronidazole, moxifloxacin and clarithromycin, while three isolates were resistant to clarithromycin. C. difficile may be an important pathogen causing diarrhoea in sub-Saharan Africa among immunocompromised patients
ER  -