TY  - BOOK
AU  -  Yustina A Tizeba
AU  - Mariam M Mirambo
AU  - Neema Kayange
AU  - Tumaini Mhada
AU  -  Emmanuela E Ambrose
AU  -  Luke R Smart
AU  - Stephen E Mshana
TI  - Parvovirus B19 Is Associated with a Significant Decrease in Hemoglobin Level among Children <5 Years of Age with Anemia in Northwestern Tanzania
SN  - Online IS
PY  - 0000/// 132017///
CY  - Mwanza, Tanzania: 
PB  -  Catholic University of Health and Allied Sciences CUHAS - Bugando &,  Oxford University Press
N2  - Abstract:

Parvovirus B19 (B19) can cause transient aplastic crisis and lead to acute severe anemia. This study investigated the relationship between B19 and anemia among children <5 years old in the city of Mwanza, Tanzania. An enzyme immunoassay was used to detect B19 IgM- and IgG-specific antibodies among children with various categories of anemia according to the World Health Organization (WHO) guidelines. A total of 265 children with median age of 28.5 months (interquartile range 18–39.5) were investigated. Eighty-six children (32.5%) had severe anemia. B19-specific IgM and IgG antibodies were detected in 24 (9%) and 46 (17.4%) children, respectively. Low hemoglobin (Hb) level (p = 0.031), Plasmodium falciparum infection (p = 0.001) and residing in rural areas (p = 0.025) independently predicted B19 IgM seropositivity. Acute B19 infection decreased Hb level by 1.1 g/dl (p = 0.003). In malaria endemic areas, acute B19 infections should be considered among children with severe anemia from rural areas
UR  - https://doi.org/10.1093/tropej/fmx099
ER  -