TY  - BOOK
AU  -  Deborah Watson-Jones
AU  - Balthazar Gumodoka
AU  -  Helen Weiss
AU  - John Changalucha
AU  - James Todd
AU  -  Kokungoza Mugeye
AU  - Anne Buvé
AU  - Zephrine Kanga
AU  -  Leonard Ndeki
AU  -  Mary Rusizoka
AU  - David Ross
AU  - Janeth Marealle
AU  -  Rebecca Balira
AU  - David Mabey
AU  - Richard Hayes
TI  - Syphilis in Pregnancy in Tanzania. II. The Effectiveness of Antenatal Syphilis Screening and Single-Dose Benzathine Penicillin Treatment for the Prevention of Adverse Pregnancy Outcomes
PY  - 0000/// 012002///
CY  - Mwanza, Tanzania  
PB  - Catholic University of Health and Allied Sciences CUHAS - Bugando
N2  - Abstract

Treatment for maternal syphilis with single-dose benzathine penicillin (2.4 million units intramuscularly) is being implemented in many parts of sub-Saharan Africa. To examine the effectiveness of this regimen, a prospective cohort of 1688 pregnant women was recruited in Tanzania. Birth outcomes were compared among women treated for high-titer (n=133; rapid plasma reagin [RPR] titer ⩾1:8 and Treponema pallidum hemagglutination assay [TPHA]/fluorescent treponemal antibody [FTA] positive) and low-titer (n=249; RPR titer <1:8 and TPHA/FTA positive) active syphilis and 950 uninfected women. Stillbirth or low-birth-weight live births were observed in 2.3% and 6.3%, respectively, of women treated for high-titer active syphilis and in 2.5% and 9.2%, respectively, of seronegative women. There was no increased risk for adverse pregnancy outcome for women treated for high-titer active syphilis (odds ratio [OR], 0.76; 95% confidence interval [CI], 0.4–1.4) or low-titer active syphilis (OR, 0.95; 95% CI, 0.6–1.5), compared with seronegative women. Single-dose treatment is effective in preventing adverse pregnancy outcomes attributable to maternal syphilis
ER  -