Quantitative pharmacology and individualized therapy strategies in development of therapeutic proteins for immune-mediated inflammatory diseases /
edited by Honghui Zhou, Diane R. Mould.
- 1 online resource.
"John Wiley & Sons Inc."--tp verso.
Includes bibliographical references and index.
"Focused on quantitative pharmacology and individualized therapy for developing biotherapeutics in immune-mediated inflammatory diseases, this book discusses both theoretical and practical aspects and includes case studies illustrating applications in drug development. Provides frontline knowledge of using PK/PD modeling tools to address a variety of problems in development of therapeutic proteins. Reviews and discusses biomarkers, systems pharmacology, PBPK modeling, and target-mediated modeling, as translational tools. Helps readers understand disease progression and identify of mechanisms-based biomarkers with clinical relevance"--Provided by publisher.
9781119289210 9781119289227
2018053075
Autoimmune Diseases--drug therapy Proteins--therapeutic use Proteins--pharmacokinetics Protein Engineering--methods Models, Theoretical