Quantitative pharmacology and individualized therapy strategies in development of therapeutic proteins for immune-mediated inflammatory diseases / edited by Honghui Zhou, Diane R. Mould. - 1 online resource.

"John Wiley & Sons Inc."--tp verso.

Includes bibliographical references and index.

"Focused on quantitative pharmacology and individualized therapy for developing biotherapeutics in immune-mediated inflammatory diseases, this book discusses both theoretical and practical aspects and includes case studies illustrating applications in drug development. Provides frontline knowledge of using PK/PD modeling tools to address a variety of problems in development of therapeutic proteins. Reviews and discusses biomarkers, systems pharmacology, PBPK modeling, and target-mediated modeling, as translational tools. Helps readers understand disease progression and identify of mechanisms-based biomarkers with clinical relevance"--Provided by publisher.

9781119289210 9781119289227

2018053075


Autoimmune Diseases--drug therapy
Proteins--therapeutic use
Proteins--pharmacokinetics
Protein Engineering--methods
Models, Theoretical

RC600

616.97/806

WD 305