Contents:

List of Contributors


A Chemists Survey of Different Antibiotic


Antibacterial Discovery Problems


Impact of Microbial Natural Products


Antibiotics and Resistance A Fatal Attraction


Fitness Costs of Antibiotic Resistance


Inhibitors of CellWall Synthesis


Inhibitors of Bacterial Cell Partitioning


Targeting Ribonuclease


Involvement of Ribosome Biogenesis


AminoacyltRNA Synthetase Inhibitors


Antibiotics Targeting Translation Initiation


References


Aminoglycoside Antibiotics Structural


Peptidyltransferase Inhibitors of the Bacterial


References


The Membrane as a Novel Target Site


Bacterial Membrane a Key for Controlling Drug


Interference with Bacterial CelltoCell


Recent Developments in Inhibitors of Bacterial


Antibiotics Targeting Bacterial


Inhibitors Targeting Riboswitches


Acknowledgments


Targeting HSP7O to Fight Cancer and


References


Index

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed.

Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic resistance, this reference systematically covers currently known antibiotic classes, their molecular mechanisms and the targets on which they act. Novel targets such as cell signaling networks, riboswitches and bacterial chaperones are covered here, alongside the latest information on the molecular mechanisms of current blockbuster antibiotics.

With its broad overview of current and future antibacterial drug development, this unique reference is essential reading for anyone involved in the development and therapeutic application of novel antibiotics.