Contents:

Multiplexed Pharmacogenetic

Role of Pharmacogenetics in Gastrointestinal Cancer

Pharmacogenomics

A Novel Factor

Current Status

Clinical Implications

Pharmacogenetics of Asthma

Pharmacogenomics in Gastroenterology

The Pharmacogenetics

Pharmacogenetics

Beyond Pharmacogenetics

The rapidly evolving field of Pharmacogenetics aims at identifying the genetic factors implicated in the inter-individual variation of drug response. These factors could enable patient sub-classification based on their treatment needs thus expediting drug development and promoting personalized, safer and more effective treatments. This book presents Pharmacogenetic examples from a broad spectrum of different drugs, for different diseases, which are representative of different stages of evaluation or application. It has been designed so as to serve both the unfamiliar reader through explanations of basic Pharmacogenetic concepts, the clinician with presentation of the latest developments and international guidelines, and the research scientist with examples of Pharmacogenetic applications, discussions on the limitations and an outlook on the new scientific trends in this field. Common terms and phrases: acid adverse drug adverse drug reactions allele frequency amodiaquine analysis antidepressant antiplatelet aspirin assay association studies asthma azathioprine biomarkers cardiovascular carriers Caucasians cells cetuximab chromosome Clin Pharmacol Ther clinical practice clopidogrel colorectal cancer correlation cytochrome P450 decreased depression detection differences disease drug metabolism drug response effects efficacy EGFR encoding enzyme epigenetic erlotinib Exon factors fluorescence function gemcitabine gene expression genetic polymorphisms genetic variants genome genome-wide GWAS haplotype hepatitis homozygous human genome increased individual inhibition inhibitors irinotecan ISSN Krynetski leukotriene levels liver malaria markers mercaptopurine metabolite methylation methyltransferase microRNA miRNA molecular mRNA MTHFR mutations nucleotide oligonucleotide pathway patients personalized medicine pharmacodynamic pharmacogenetic testing pharmacogenetics pharmacology phenotype platelet PON1 population predict protein Puerto Ricans reactions receptor relevant resistance risk role samples sequence significant SNP genotyping target therapeutic thiopurine drugs thiopurine S-methyltransferase toxicity TPMT activity TPMT gene treatment variability VKORC1 warfarin warfarin dose Weinshilboum women