Contents:

Preface

Clinically Isolated Syndrome

1 Optic neuritis

2 Myelitis

Early Multiple Sclerosis

3 Diseasemodifying therapies

4 Management of relapses withcorticosteroids

Established RelapsingRemitting Multiple Sclerosis

10 Diagnosing secondary progressive multiple sclerosis

11 Walking disability in multiplesclerosis

12 Cognitive impairment

Pediatric Multiple Sclerosis and Related Disorders

13 Acute disseminatedencephalomyelitis

14 Pediatric multiple sclerosis

15 Pediatric multiple sclerosis mimics

Pregnancy and Multiple Sclerosis


5 Breakthrough disease

6 Progressive multifocalleukoencephalopathy

7 Induction therapy

Primary Progressive Multiple Sclerosis

8 Diagnosing primary progressive multiple sclerosis

9 Symptomatic care in primary progressive multiple sclerosis

Secondary Progressive Multiple Sclerosis

16 Prenatal planning in multiplesclerosis

17 Multiple sclerosis therapies and pregnancy

18 Postpartum issues with multiple sclerosis

Other Multiple SclerosisRelated Disorders

19 Neuromyelitis optica

This handbook is a collection of clinical narratives that underscore the heterogeneous and unpredictable presentation of multiple sclerosis (MS) and give real-world clinical context to recent drug developments. This accessible and concise publication is intended to be used by a wide range of medical professionals, from specialist neurologists to medical trainees with an interest in neurology. An ideal clinical resource, Case Studies in Multiple Sclerosis provides an evidence-based discussion of each case, with an aim to enhance effective diagnosis and treatment of patients with MS and MS-related conditions. Common terms and phrases: acute ADEM alemtuzumab Ann Neurol antibody assessment attempting conception bilateral brain MRI brainstem cerebrospinal fluid Clinical pearls clinical trials clinically isolated syndrome corticosteroids diagnosis diagnostic criteria disability disease activity disorders DMTs EDSS enhancement etal evaluation examination fampridine fingolimod follow-up gadolinium gadolinium-enhancing glatiramer acetate imaging infection inflammatory interferon beta-1a International Publishing Switzerland intravenous Investigations involvement juxtacortical lesions lesions on MRI long-term McDonald criteria medications methylprednisolone mild MRI lesions multiple sclerosis MultScler myelitis natalizumab Neurology neuromyelitis optica neuropathic pain normal Ó Springer O’Connor oligoclonal bands onset optic nerve optic neuritis Outcome P.S. Giacomini periventricular placebo-controlled Polman CH pregnancy primary progressive progressive multifocal leukoencephalopathy progressive multiple sclerosis Publishing Switzerland 2017 relapsing-remitting multiple sclerosis secondary progressive spinal cord SPMS Springer International Publishing Studies in Multiple Study Group Switzerland 2017 P.S. T2 hyperintense T2 lesions teriflunomide testing therapeutic treatment typical visual white matter worsening