Contents:

Introduction

Epidemiology Risk Factors and Survival in CUP Pointers to Disease Mechanisms

Biologic Features of CUP

Prognostic Factors and Their Role in the Management of CUP

Diagnostic Workup of CUP An Approach to Current Recommendations and Underlying Evidence

The Radiologists Approach to CUP

Cancer of Unknown Primary The Pathologists Approach

Treatment of Disseminated CUP

Concepts of Radiotherapy in Cancer of Unknown Primary

Favorable Subsets Among Cancers of Unknown Primary

Novel Diagnostic and Therapeutic Strategies in the Management of Patients with Cancers of Unknown Primary Site

Future Directions

This book presents an up-to-date and thorough overview of cancer of unknown primary, encompassing topics ranging from epidemiology, tumor biology, and prognostic factors through to the most recent diagnostic and therapeutic advances. All aspects of management are covered, including radiological, nuclear medicine, and pathological diagnosis, site-specific therapies, platinum-based combination chemotherapy, radiotherapy, and novel targeted treatments. Clear guidance is offered on diagnosis of the tissue of origin by means of gene expression and micro-RNA analyses and its therapeutic implications. Detailed directions are also provided on the identification of subsets of patients with a more favorable prognosis, in whom specific treatment offers the chance of long-term survival or even cure. Readers will find Cancer of Unknown Primary to be an ideal source of practically oriented information that will assist in delivery of the best possible care for patients with this challenging diagnosis. Common terms and phrases: adenocarcinoma analysis biopsy brain metastases breast cancer cancer classifier assays cancer of unknown cancer types carcinoma of unknown cervical CUP cervical lymph nodes chemotherapy cisplatin Clin Oncol clinical colorectal cancer CUP patients detection diagnostic disease evaluation favorable subset gemcitabine gene expression profiling genetic germ cell tumors Greco guidelines Hainsworth JD head and neck Hemminki histological identified IHC staining imaging immunohistochemical immunohistochemistry lesion Löffler lung cancer lymph node metastases lymphoma malignant markers median survival melanoma molecular cancer classifier molecular profiling months mutations neuroendocrine tumors nodal occult primary Oncology Pathol pathological patients with carcinoma patients with CUP Pavlidis Pentheroudakis performance status peritoneal poorly differentiated carcinoma primary cancer primary sites primary tumor prognostic factors Pubmed Central PubMed Epub PubMed PMID Radiat Oncol Biol radiotherapy renal cell carcinoma site-specific therapy specific Spigel DR squamous cell carcinoma subgroups targeted therapeutic tissue of origin treatment trials ultrasound unknown primary