Contents:

Imaging Insights into Mechanisms of Calcific Aortic Valve Disease CAVD and Calcification

Clinical Imaging of Cardiovascular Inflammation and Calcification

Index

This book provides comprehensive reviews on our most recent understanding of the molecular and cellular mechanisms underlying atherosclerosis and calcific aortic valve disease (CAVD) as visualized in animal models and patients using optical molecular imaging, PET-CT, ultrasound and MRI. In addition to presenting up-to-date information on the multimodality imaging of specific pro-inflammatory or pro-calcification pathways in atherosclerosis and CAVD, the book addresses the intriguing issue of whether cardiovascular calcification is an inflammatory disease, as has been recently supported by several preclinical and clinical imaging studies. In order to familiarize researchers and clinicians from other specialties with the basic mechanisms involved, chapters on the fundamental pathobiology of atherosclerosis and CAVD are also included. The imaging chapters, written by some of the foremost investigators in the field, are so organized as to reveal the nature of the involved mechanisms as disease progresses. Common terms and phrases:

activity adhesion molecules Aikawa angiography antibodies aorta aortic stenosis aortic valve arterial inflammation arterial wall Arterioscler Thromb Vasc assessment associated atherosclerotic lesions atherosclerotic plaques blood calcification calcium cardiac cathepsin CAVD cholesterol Circ Circulation clinical collagen contrast agent correlated demonstrated dendrimers detection diabetes echocardiography endothelial cells evaluation Fayad FDG uptake FDG-PET/CT imaging fibrous cap fluorescence high-risk human increased inflammation inflammatory injection iron oxide ischemia IVUS JACC Cardiovasc Imaging Jaffer JAm Coll Cardiol left ventricular leukocytes Libby lipid lipoprotein macrophages magnetic resonance imaging marker matrix metabolic mice micelles microbubbles molecular imaging myocardial infarction nanoparticles necrotic core NIRF imaging noninvasive Nucl optical OSE-targeted P-selectin patients peptide PET/CT pioglitazone plaque inflammation plaque rupture platelet positron emission tomography preclinical probes protease protein risk signal statins stent studies Tahara targeted techniques therapy Thromb Vasc Biol thrombus tion tissue Tsimikas ultrasound valvular vessel visualize vulnerable plaque Weissleder