Contents:

Chapter 1 Genetics of Neonatal Jaundice

Chapter 2 Bilirubin Production and its Measurement

Chapter 3 Bilirubin and its Various Fractions

Chapter 4 Bilirubin Metabolism and Transport

Chapter 5 Physiology of Neonatal Unconjugated Hyperbilirubinemia

Chapter 6 The Epidemiology of Neonatal Hyperbilirubinemia

Chapter 7 Bilirubin Toxicity

Chapter 8 Hemolytic Disorders and Their Management

Chapter 9 Prevention Screening and Postnatal Management of Neonatal Hyperbilirubinemia

Chapter 10 Phototherapy and Other Treatments

Chapter 11 Kernicterus

Chapter 12 Public Policy to Prevent Severe Neonatal Hyperbilirubinemia

Chapter 13 Neonatal Jaundice in Low and MiddleIncome Countries

Index

Care of the Jaundiced Neonate:

A complete, authoritative guide to the management and treatment of neonatal jaundice

Care of the Jaundiced Neonate focuses exclusively on the scientific underpinnings of jaundice, as well as the care of the jaundiced neonate. Edited by three of the field’s most respected neonatal care experts, the book uniquely explains how the imbalance between bilirubin production and elimination leads to jaundice—and that hazardous levels of unconjugated bilirubin can cause kernicterus, or brain damage. In addition, you’ll find the most current and clinically relevant perspectives on the physiology, genetics, and treatment of neonatal jaundice and related hemolytic conditions.

FEATURES

Covers all aspects of neonatal jaundice—from the biochemistry of bilirubin production to kernicterus
Begins with an in-depth examination of the complex gene-environment interactions of bilirubin-induced neurotoxicity and its role in neonatal jaundice
Surveys bilirubin production and measurement, its various fractions, and the metabolism and transport of bilirubin
Selected chapters highlight the physiology and epidemiology of neonatal unconjugated hyperbilirubinemia; bilirubin toxicity; prevention, screening, and postnatal management; phototherapy and other treatments; and prevention-related public policy.
Concluding chapter provides an overview of the key issues surrounding the incidence of neonatal jaundice in low-middle income countries
Includes informative review of risk assessment and treatment with phototherapy and other modalities provide key approaches to the effective clinical management of neonatal hyperbilirubinemia Common terms and phrases:


95th percentile abnormal Acta Paediatr activity albumin Arch Dis Child associated astrocytes auditory Bhutani Bhutani VK biliru bilirubin encephalopathy bilirubin levels bilirubin production bilirubinemia BIND birth weight brain breastfeeding cell Clin clinical conjugated Crigler–Najjar decreased effect enterohepatic circulation enzyme exchange transfusion excretion Figure free bilirubin G6PD deficiency gene genetic gestational age Gilbert syndrome glucose-6-phosphate dehydrogenase glucose-6-phosphate dehydrogenase deficiency glucuronosyltransferase Hammerman heme oxygenase hemolysis hemolytic disease hepatic hereditary spherocytosis hyper hyperbili increased irradiance Kaplan kernicterus liver Maisels MJ membrane metabolism mg/dL microglia mutations neonatal hyperbilirubinemia neonatal jaundice neurologic neurons neurotoxicity newborn infant Newman TB nomogram normal oxidative Pediatr Res Pediatrics Perinatol phototherapy polymorphism predischarge preterm infants prevent protein risk factors rubinemia screening serum bilirubin severe hyperbilirubinemia severe neonatal Shapiro SM significant Stevenson DK TcB measurements term infants tion toxicity transcutaneous treatment TSB levels unconjugated bilirubin Vreman HJ Watchko JF Wong RJ