Section I, Medical Treatment Of Bone Metastases: 1 Bone metastasis microenvironment -- 2 Cancer treatment induced bone loss -- 3 Bone targeted therapies in adjuvant setting -- 4 New therapeutic targets in metastatic setting -- 5 Pain in bone metastatic patients. Section II, Imaging / Radiology / Radiotherapy And Pathology: 6 The role of radiotherapy in bone metastasis -- 7 Pathology of bone metastasis -- 8 Pathology: difficult cases -- 9 Diagnostic imaging of bone metastases. Section III, Approach To The Patient: 10 The Pathfx project: decision analysis and Bayesian method in survival estimation -- 11 The choice of surgical procedure: how a surgeons choice is influenced by the expected survival -- 12 Metastases to the spine: algorithm of treatment -- 13 Metastases to the long bones: algorithm of treatment -- 14 Metastases to the pelvis: algorithm of treatment -- 15 Pathological vs Impending Fracture -- 16 Thromboprophylaxis in bone metastatic patients. Section IV, Surgery: 17 The timing of surgical treatment -- 18 Long bone metastasis -- 19 Spine Bone Metastasis Approach -- 20 Metastases to the sacrum and pelvis -- 21 New biomaterials in instrumentation systems: Carbon fiber intramedullary nail -- 22 New biomaterials in instrumentation system: Photodynamic Bone stabilization System -- 23 Fractures around tumor implants -- 24 Demolitive Surgery: is it an option? -- 25 Rehabilitation of patients with bone metastatic disease -- 26 Think, stage, then act -- 27 Pitfalls, Errors, and Unintended Consequences in the treatment of metastatic bone disease: how they occur and how they can be avoided. Section V, Minimally Invasive Tumor Treatment: 28 Interventional radiology, Thermoablation and Cryoablation -- 29 Electrochemotherapy -- 30 MRI-guided focused ultrasound surgery -- 31 New Palliative techniques: indications and limits.