Prevalence and Factors Associated with Colonization of Carbepenem Resistant Gram-Negative Bacteria Among Patients with Skin and Soft Tissue Infections Admited at Bugando Medical Centre in Mwanza, Tanzania.
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TextPublisher number: Wurzburg Road 35, Premises, Post Code: 33102 | P. O. Box 1464 Mwanza, Tanzania | Phone: (255) 28-298-3384 | Fax: (255) 28-298-3386 |Email: vc@bugando.ac.tz | Website: www.bugando.ac.tz Language: English Language: Kiswahili Publication details: Mwanza, Tanzania | Catholic University of Health and Allied Sciences [CUHAS-Bugando] | 2024. Description: 57 Pages; Includes ReferencesSubject(s): Summary:
Abstract:
Background: Carbapenem-resistant Gram-negative bacteria (CR-GNB) colonization pose a significant risk for endogenous skin and soft tissue infections (SSTIs) associated with high morbidity and mortality, owing to limited antimicrobial therapeutic options. However, there is limited data on CR-GNB colonizing skin and soft tissue patients admitted at BMC which necessitate the aims to provide insight on the prevalence, factor associated with CR-GNB colonizing patients with SSTIs admitted at Bugando Medical Centre (BMC), Mwanza, Tanzania.
Methods. A cross-sectional study was conducted on 202 patients with SSTIs at BMC, involving rectal swabs and stool samples. Isolated bacteria were identified using biochemical tests, including disk diffusion testing for CR-GNB screening and combined disk tests for phenotypic confirmation. Data was analyzed using STATA version 15.0.
Results: A total of 202 patients with SSTIs with median age of 30 [18-49] years admitted at BMC were enrolled in this study. The majority of patients were males 129 (63.8%). The prevalence of rectal colonization with 3GC-R-GNB was 95.53% (n=193) with a total of 247 bacterial species detected. Predominantly, E. coli 63.97%% (158/247) and K. pneumoniae 23.48% (58/247) were identified. The prevalence of patients with SSTIs colonized with ESBL-PE phenotypes was 76.24% (154/202) while the proportion of CRGNB phenotypes colonization was 12.96% (32/247).
Conclusion: The study found 14.85% CR-GNB colonizing patients with SSTIs admitted at BMC, emphasizing the need for enhanced infection prevention and control measures to prevent and minimize subsequent endogenous MDR – SSTIs by CR-GNB.
Abstract:
Background: Carbapenem-resistant Gram-negative bacteria (CR-GNB) colonization pose a significant risk for endogenous skin and soft tissue infections (SSTIs) associated with high morbidity and mortality, owing to limited antimicrobial therapeutic options. However, there is limited data on CR-GNB colonizing skin and soft tissue patients admitted at BMC which necessitate the aims to provide insight on the prevalence, factor associated with CR-GNB colonizing patients with SSTIs admitted at Bugando Medical Centre (BMC), Mwanza, Tanzania.
Methods. A cross-sectional study was conducted on 202 patients with SSTIs at BMC, involving rectal swabs and stool samples. Isolated bacteria were identified using biochemical tests, including disk diffusion testing for CR-GNB screening and combined disk tests for phenotypic confirmation. Data was analyzed using STATA version 15.0.
Results: A total of 202 patients with SSTIs with median age of 30 [18-49] years admitted at BMC were enrolled in this study. The majority of patients were males 129 (63.8%). The prevalence of rectal colonization with 3GC-R-GNB was 95.53% (n=193) with a total of 247 bacterial species detected. Predominantly, E. coli 63.97%% (158/247) and K. pneumoniae 23.48% (58/247) were identified. The prevalence of patients with SSTIs colonized with ESBL-PE phenotypes was 76.24% (154/202) while the proportion of CRGNB phenotypes colonization was 12.96% (32/247).
Conclusion: The study found 14.85% CR-GNB colonizing patients with SSTIs admitted at BMC, emphasizing the need for enhanced infection prevention and control measures to prevent and minimize subsequent endogenous MDR – SSTIs by CR-GNB.
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