Prevalence and Factors Associated with Carbapenem-Resistant Gram-Negative Bacteria Causing Skin and Soft Tissue Infections Among Inpatients at Bugando Medical Centre, Mwanza, Tanzania.
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TextPublisher number: Wurzburg Road 35, Premises, Post Code: 33102 | P. O. Box 1464 Mwanza, Tanzania | Phone: (255) 28-298-3384 | Fax: (255) 28-298-3386 | Email: vc@bugando.ac.tz | Website: www.bugando.ac.tz Language: English Language: Kiswahili Publication details: Mwanza, Tanzania | Catholic University of Health and Allied Sciences [CUHAS-Bugando] | 2024. Description: 51 Pages; Includes ReferencesSubject(s): Summary: Abstract:
Background: SSTIs caused by carbapenem-resistant Gram-negative bacteria (CR-GNB) is associated with high morbidity and mortality. Currently, limited knowledge exists on SSTIs by CR-GNB from low- and middle-income countries including Tanzania. The aim of this study is to determine the prevalence and factors associated with SSTIs by CR-GNB among inpatients at Bugando Medical Centre (BMC), Mwanza, Tanzania.
Methods: This study was conducted on 202 inpatients with SSTIs in BMC, Mwanza, Tanzania, using a cross-sectional hospital-based approach. Data was collected through a structured questionnaire, Pus swab samples were cultured, and bacteria were identified using convectional biochemical tests. Then data were exported to STATA software version 15, chi-square analysis and two proportion tests used to analyze the data.
Results: A total of 202 patients, with a median age of 30[18-49] years were recruited in this study. The majority of the participants were male 129 (63.8%). A total of 141 (69.8%) samples were culture positive, resulting into a total of 186 microorganisms isolated. Pathogens isolated were mostly GNB 167(89.8%), P. aeruginosa and E. coli were the most frequent isolated GNB 45(24.2%) and 43(23.1%) respectively. The prevalence of CR-GNB causing SSTIs was found to be 18.3% observed predominantly in Acinetobacter spp 14(37.8%) and P. aeruginosa 13(35.1%). Long hospital stays 22[8-40] days and prolonged use of treatment antibiotics 15[5-29] days were significantly associated with CR-GNB causing SSTIs (p=0.0037) and (p=0.0068) respectively.
Conclusion: SSTIs by CR-GNB were found to be higher among inpatients at BMC and found to commonly associate with multiple factors. Strategies to control these factors are urgently needed to control SSTIs by CR-GNB among inpatients at BMC and other centers in developing countries.
| Item type | Current library | Status | Barcode | |
|---|---|---|---|---|
| UNDERGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | Not for loan | 20240920113030.0 |
Abstract:
Background: SSTIs caused by carbapenem-resistant Gram-negative bacteria (CR-GNB) is associated with high morbidity and mortality. Currently, limited knowledge exists on SSTIs by CR-GNB from low- and middle-income countries including Tanzania. The aim of this study is to determine the prevalence and factors associated with SSTIs by CR-GNB among inpatients at Bugando Medical Centre (BMC), Mwanza, Tanzania.
Methods: This study was conducted on 202 inpatients with SSTIs in BMC, Mwanza, Tanzania, using a cross-sectional hospital-based approach. Data was collected through a structured questionnaire, Pus swab samples were cultured, and bacteria were identified using convectional biochemical tests. Then data were exported to STATA software version 15, chi-square analysis and two proportion tests used to analyze the data.
Results: A total of 202 patients, with a median age of 30[18-49] years were recruited in this study. The majority of the participants were male 129 (63.8%). A total of 141 (69.8%) samples were culture positive, resulting into a total of 186 microorganisms isolated. Pathogens isolated were mostly GNB 167(89.8%), P. aeruginosa and E. coli were the most frequent isolated GNB 45(24.2%) and 43(23.1%) respectively. The prevalence of CR-GNB causing SSTIs was found to be 18.3% observed predominantly in Acinetobacter spp 14(37.8%) and P. aeruginosa 13(35.1%). Long hospital stays 22[8-40] days and prolonged use of treatment antibiotics 15[5-29] days were significantly associated with CR-GNB causing SSTIs (p=0.0037) and (p=0.0068) respectively.
Conclusion: SSTIs by CR-GNB were found to be higher among inpatients at BMC and found to commonly associate with multiple factors. Strategies to control these factors are urgently needed to control SSTIs by CR-GNB among inpatients at BMC and other centers in developing countries.
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