Prevalence and Associated Risk Factors for Liver Stiffness among Patients with Chronic Hepatitis B Infection Using Fibroscan at Bugando Medical Centre.
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TextPublisher number: Wurzburg Road 35, Premises, Post Code: 33102 | P. O. Box 1464 Mwanza, Tanzania | Phone: (255) 28-298-3384 | Fax: (255) 28-298-3386 | Email: vc@bugando.ac.tz | Website: www.bugando.ac.tz. Language: English Language: Kiswahili Publication details: Mwanza, Tanzania | Catholic University of Health and Allied Sciences [CUHAS-Bugando] | 2024.Description: 31 Pages; Includes ReferencesSubject(s): Summary: Abstract:
Background: Chronic hepatitis B is a significant global health concern, and liver fibrosis is a common complication. This study aimed to determine the prevalence of liver stiffness in Tanzanian CHB patients and identify the associated risk factors.
Methods: A cross-sectional study of consecutive chronic hepatitis B patients performed VCTE and followed up at BMC Hospital, Mwanza, Tanzania, was conducted between 1 November, 2023, and 26 August, 2024. Liver fibrosis was defined as minimal (METAVIR F0-1) by LSM≤ 7.0 kPa and significant (METAVIR F2-4) by LSM ≥ 7.1 kPa. LSM assessments and medical records were retrospectively reviewed. The prevalence and determinants of significant liver fibrosis were analyzed.
Results: A total of 211 eligible patients were included; 143 patients (67.8%) were male. The mean age was 41.41 years (SD 10.92 years), and 57.3% had a body mass index ≥ 25 kg/m2. The prevalence of significant fibrosis (F2-4) were 44.1%. Significant determinants of significant fibrosis (F2-4) were male gender, advanced age and elevated liver biochemistries.
Conclusion: Approximately half of the Tanzanian patients with chronic viral hepatitis B had significant liver disease defined by Fibroscan, requiring further evaluation for specific treatment for hepatitis B virus. Determinants of significant liver fibrosis were male gender and high AST level.
| Item type | Current library | Status | Barcode | |
|---|---|---|---|---|
| UNDERGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | Not for loan | 20240903155935.0 |
Abstract:
Background: Chronic hepatitis B is a significant global health concern, and liver fibrosis is a common complication. This study aimed to determine the prevalence of liver stiffness in Tanzanian CHB patients and identify the associated risk factors.
Methods: A cross-sectional study of consecutive chronic hepatitis B patients performed VCTE and followed up at BMC Hospital, Mwanza, Tanzania, was conducted between 1 November, 2023, and 26 August, 2024. Liver fibrosis was defined as minimal (METAVIR F0-1) by LSM≤ 7.0 kPa and significant (METAVIR F2-4) by LSM ≥ 7.1 kPa. LSM assessments and medical records were retrospectively reviewed. The prevalence and determinants of significant liver fibrosis were analyzed.
Results: A total of 211 eligible patients were included; 143 patients (67.8%) were male. The mean age was 41.41 years (SD 10.92 years), and 57.3% had a body mass index ≥ 25 kg/m2. The prevalence of significant fibrosis (F2-4) were 44.1%. Significant determinants of significant fibrosis (F2-4) were male gender, advanced age and elevated liver biochemistries.
Conclusion: Approximately half of the Tanzanian patients with chronic viral hepatitis B had significant liver disease defined by Fibroscan, requiring further evaluation for specific treatment for hepatitis B virus. Determinants of significant liver fibrosis were male gender and high AST level.
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