Includes bibliographical references and index.

Introduction: still more questions than answers / William Jagust and Mark D'Esposito -- Methodological and conceptual issues in the study of the aging brain / Mark D'Esposito, William Jagust, and Adam H. Gazzaley -- Neuropathology of aging / Dara L. Dickstein, John H. Morrison, and Patrick R. Hof -- A systems approach to the aging brain : neuroanatomic changes, their modifiers, and cognitive correlates / Naftali Raz and Kristen M. Kennedy -- Dopaminergic modulation of cognition in human aging / Shu-Chen Li ... [et al.] -- Cognitive reserve and aging / Yaakov Stern -- Compensatory reorganization of brain networks in older adults / Cheryl L. Grady -- Cross-species imaging applied to the aging brain : dissociating Alzheimer's disease from normal aging / Sidonie T. Jones and Scott A. Small -- Genetics and imaging in Alzheimer's disease / Susan Y. Bookheimer -- Imaging cognitive decline in aging : predicting decline with structural imaging / Jeffrey Kaye -- The early detection of Alzheimer's disease with positron emission tomography / Rachel Mistur ... [et al.] -- Structural imaging of mild cognitive impairment / Clifford R. Jack, Jr. -- Functional imaging with FDG-PET in mild cognitive impairment / Karl Herholz -- Amyloid imaging and (what is "normal"?) aging / William E. Klunk and Chester A. Mathis -- Differential diagnosis of dementia using functional neuroimaging / Eric Salmon, Fabienne Collette, and Gaëtan Garraux -- MRI and the differential diagnosis of dementia / António J. Bastos-Leite and Philip Scheltens -- White matter hyperintensities in aging and dementia / Adriane Mayda, Mitsuhiro Yoshita, and Charles DeCarli -- Functional MRI studies in aging and early Alzheimer's disease : predicting clinical decline / Reisa Sperling -- MRI as a surrogate marker in clinical trials in Alzheimer's disease / Frank Jessen and Harald Hampel -- Brain imaging in the evaluation of putative Alzheimer's disease-slowing, risk-reducing and prevention therapies / Eric M. Reiman and Jessica B.S. Langbaum -- Databasing the aging brain / John Darrell Van Horn and Arthur W. Toga.